Protein Information

Cytoscape View

UniProt AC / UniProt ID P43026 / GDF5_HUMAN
Protein Name Growth/differentiation factor 5 precursor
Gene Name Name: GDF5
Organism Homo sapiens (Human)

PRO ID PR:P43026
DAG View
PRO Name growth/differentiation factor 5 (human)
Definition A growth/differentiation factor 5 that is encoded in the genome of human.
Short Label hGDF5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P43026 (GDF5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y222 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000000437 (hGDF5/var:C400Y) Interaction PR:000000164 (BMP2) PRO 9288098
PR:000036543 (hGDF5/iso:1/Clv:1) Interaction PR:P12643 (hBMP2) PRO 9288098

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y222 C222 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T249 M249 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1612 / breast cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S475 N475 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]