iPTMnet Report for P42898 (MTHFR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42898 / MTHR_HUMAN
Protein Name Methylenetetrahydrofolate reductase (NADPH)
Gene Name Name: MTHFR
Organism Homo sapiens (Human)

PRO ID PR:P42898
DAG View
PRO Name methylenetetrahydrofolate reductase (NADPH) (human)
Definition A methylenetetrahydrofolate reductase (NADPH) that is encoded in the genome of human.
Short Label hMTHFR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42898 (MTHFR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation UniProt 29891918
S10 Phosphorylation UniProt 29891918
S18 Phosphorylation UniProt 29891918
S20 Phosphorylation UniProt 29891918
S21 Phosphorylation UniProt 29891918
S23 Phosphorylation UniProt 29891918
S25 Phosphorylation UniProt 29891918
S26 Phosphorylation RLIMS-P   UniProt 29891918, 30862944
S29 Phosphorylation UniProt 29891918
S30 Phosphorylation RLIMS-P   UniProt 29891918, 30862944
S33 Phosphorylation RLIMS-P 30862944
T34 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30862944, 28820331, 16024724, ...29891918, 24769206
Y90 Phosphorylation PhosphoSitePlus   UniProt 29891918
T94 Phosphorylation UniProt 29891918
S103 Phosphorylation UniProt 29891918
K151 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S394 Phosphorylation UniProt 29891918
K414 Ubiquitination PhosphoSitePlus
T451 Phosphorylation UniProt 29891918
K468 Ubiquitination PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus   RLIMS-P 28820331
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 16024724
S20 Phosphorylation HPRD 16024724
S21 Phosphorylation HPRD 16024724
S26 Phosphorylation HPRD 16024724
S29 Phosphorylation HPRD 16024724
S30 Phosphorylation HPRD 16024724
S33 Phosphorylation HPRD 16024724
T34 Phosphorylation HPRD 16024724


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 N20 Biomuta DOID:4159 / skin cancer [ cosmic ]
S23 R23 Biomuta [ cosmic ]
S26 T26 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S30 L30 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S33 Y33 Biomuta DOID:4159 / skin cancer [ cosmic ]
K414 N414 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T549 S549 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]