Protein Information

Cytoscape View


UniProt AC / UniProt ID P42892 / ECE1_HUMAN
Protein Name Endothelin-converting enzyme 1
Gene Name Name: ECE1
Organism Homo sapiens (Human)

PRO ID PR:P42892
DAG View
PRO Name endothelin-converting enzyme 1 (human)
Definition An endothelin-converting enzyme 1 that is encoded in the genome of human.
Short Label hECE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42892 (ECE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus   UniProt 19690332
S34 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus 18669648, 17081983, 12244060
S36 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus 18669648, 12244060
Y41 Phosphorylation PhosphoSitePlus
S51 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
N166 N-Glycosylation UniProt 19159218, 19349973
K177 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
N210 N-Glycosylation UniProt 16263699, 19159218, 19349973
N270 N-Glycosylation UniProt 19159218
K271 Ubiquitination PhosphoSitePlus
N316 N-Glycosylation UniProt 19159218
Y331 Phosphorylation PhosphoSitePlus
N362 N-Glycosylation UniProt 19349973
N383 N-Glycosylation UniProt 19349973
K416 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S36 Phosphorylation HPRD 19651622, 18669648
S51 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
T9 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26543229
S18 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26543229
S20 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26543229
S35 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K197 R197 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K271 N271 Biomuta DOID:363 / uterine cancer [ tcga ]