iPTMnet Report for P42892 (ECE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42892 / ECE1_HUMAN
Protein Name Endothelin-converting enzyme 1
Gene Name Name: ECE1
Organism Homo sapiens (Human)

PRO ID PR:P42892
DAG View
PRO Name endothelin-converting enzyme 1 (human)
Definition An endothelin-converting enzyme 1 that is encoded in the genome of human.
Short Label hECE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42892 (ECE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
T20 O-Glycosylation GlyGen 30379171, 33214551, 33465208, ...35289036, 34019948
K22 Acetylation IEDB 34357683
T25 Phosphorylation PhosphoSitePlus   UniProt 19690332
S34 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus 18669648, 17081983, 12244060
S36 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus 18669648, 12244060
Y41 Phosphorylation PhosphoSitePlus
S51 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C58 Methylation IEDB 31844290
T63 Phosphorylation IEDB 35494241
N166 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 24190977, ...19159218, 19349973
K177 Ubiquitination PhosphoSitePlus
N187 N-Glycosylation GlyGen 29741879, 24190977
K197 Ubiquitination PhosphoSitePlus
N210 N-Glycosylation GlyGen   UniProt 16263699, 29741879, 24190977, ...19159218, 19349973
N247 N-Glycosylation GlyGen 24190977
N249 N-Glycosylation GlyGen 24190977
N251 N-Glycosylation GlyGen 24190977
N270 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
K271 Ubiquitination PhosphoSitePlus
N274 N-Glycosylation GlyGen 24190977
N316 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
Y331 Phosphorylation PhosphoSitePlus
N362 N-Glycosylation GlyGen   UniProt 19349973
N383 N-Glycosylation GlyGen   UniProt 24190977, 19349973
C388 Methylation IEDB 31844290
K416 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
N539 N-Glycosylation GlyGen 29741879, 24190977
N632 N-Glycosylation GlyGen 29741879
S633 O-Glycosylation GlyGen 30379171, 33214551, 33465208, ...35289036, 34019948
K639 Ubiquitination PhosphoSitePlus
C644 Methylation IEDB 31844290
K676 Ubiquitination PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S36 Phosphorylation HPRD 19651622, 18669648
S51 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
T9 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26543229
S18 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26543229
S20 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 26543229
S35 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K197 R197 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N247 T247 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K271 N271 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N274 K274 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N362 D362 Biomuta DOID:9256 / colorectal cancer [ cosmic ]