iPTMnet Report for P42858 (HTT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42858 / HD_HUMAN
Protein Name Huntingtin
Gene Name Name: HTT
Synonyms:HD,IT15;
Organism Homo sapiens (Human)

PRO ID PR:P42858
DAG View
PRO Name huntingtin (human)
Definition A huntingtin that is encoded in the genome of human.
Short Label hHTT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42858 (HTT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus   RLIMS-P 20026656, 32805086, 26106822, ...32757223
K6 Acetylation PhosphoSitePlus
K6 Sumoylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
K9 Acetylation PhosphoSitePlus   UniProt 21685499
K9 Sumoylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
S13 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus   RLIMS-P   Signor 32757223, 28698602, 30185623, ...20026656, 32805086
K15 Acetylation PhosphoSitePlus
K15 Sumoylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus   RLIMS-P 20026656, 30185623, 28698602
K96 Acetylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
R116 Methylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus   UniProt 21685499
K234 Acetylation PhosphoSitePlus   UniProt 21685499
K253 Ubiquitination PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
C278 S-Nitrosylation dbSNO 26338901
K335 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K343 Acetylation PhosphoSitePlus   UniProt 21685499
T405 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus   UniProt 18669648
S415 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S419 Phosphorylation O00141 (SGK1) , P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus   Signor 14725621, 12062094, 16452687, ...20166139, 15843398
S429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation Q00535 (CDK5) HPRD   neXtProt   PhosphoSitePlus   UniProt 19651622, 15911879, 19690332, ...24275569
S436 Phosphorylation PhosphoSitePlus
K442 Acetylation PhosphoSitePlus   UniProt 21685499
K442 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
G551 Myristoylation UniProt 29802276, 24459296
S620 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus   UniProt 23186163
S642 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus   UniProt 23186163
T654 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
C807 Methylation IEDB 31844290
K813 Ubiquitination PhosphoSitePlus
K824 Acetylation PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus
T1120 Phosphorylation PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
T1173 Phosphorylation PhosphoSitePlus
S1177 O-Glycosylation GlyGen 23301498, 30379171, 29351928
S1177 Phosphorylation PhosphoSitePlus
S1179 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17611284, 33572172
S1195 Phosphorylation PhosphoSitePlus
S1199 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17611284, 23186163, 33572172
S1210 Phosphorylation PhosphoSitePlus
T1215 Phosphorylation PhosphoSitePlus
K1223 Ubiquitination PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus
K1244 Ubiquitination PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
T1282 Phosphorylation PhosphoSitePlus
T1322 Phosphorylation PhosphoSitePlus
K1337 Ubiquitination PhosphoSitePlus
S1347 O-Glycosylation GlyGen 23301498, 30379171, 29351928
S1348 O-Glycosylation GlyGen 23301498, 30379171, 29351928
S1348 Phosphorylation PhosphoSitePlus
S1349 Phosphorylation PhosphoSitePlus
Y1355 Phosphorylation PhosphoSitePlus
K1402 Ubiquitination PhosphoSitePlus
K1410 Ubiquitination PhosphoSitePlus
K1415 Ubiquitination PhosphoSitePlus
K1431 Ubiquitination PhosphoSitePlus
S1644 Phosphorylation IEDB 32387766
S1674 Phosphorylation IEDB 35494241
S1789 O-Glycosylation GlyGen 23301498, 30379171, 29351928
T1796 O-Glycosylation GlyGen 23301498, 30379171, 29351928
S1805 Phosphorylation PhosphoSitePlus
C1808 Methylation IEDB 31844290
S1811 Phosphorylation PhosphoSitePlus
Y1813 Phosphorylation PhosphoSitePlus
T1814 Phosphorylation PhosphoSitePlus
S1862 Phosphorylation PhosphoSitePlus
S1864 Phosphorylation PhosphoSitePlus
S1865 Phosphorylation PhosphoSitePlus
T1866 Phosphorylation PhosphoSitePlus
S1870 Phosphorylation PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
S1874 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1880 Phosphorylation PhosphoSitePlus
K1885 Ubiquitination PhosphoSitePlus
C1976 Methylation IEDB 31844290
R2051 Methylation PhosphoSitePlus
S2074 Phosphorylation PhosphoSitePlus
S2112 Phosphorylation PhosphoSitePlus
S2114 Phosphorylation PhosphoSitePlus
S2233 Phosphorylation PhosphoSitePlus
T2335 Phosphorylation PhosphoSitePlus
K2337 Acetylation PhosphoSitePlus
S2340 Phosphorylation PhosphoSitePlus
S2382 O-Glycosylation GlyGen 23301498, 30379171, 29351928
S2382 Phosphorylation PhosphoSitePlus
T2389 O-Glycosylation GlyGen 23301498, 30379171, 29351928
K2417 Ubiquitination PhosphoSitePlus
S2421 Phosphorylation PhosphoSitePlus
K2423 Ubiquitination PhosphoSitePlus
K2443 Ubiquitination PhosphoSitePlus
K2537 Ubiquitination PhosphoSitePlus
S2548 Phosphorylation PhosphoSitePlus
K2564 Ubiquitination PhosphoSitePlus
S2651 Phosphorylation PhosphoSitePlus
T2654 Phosphorylation PhosphoSitePlus
S2655 Phosphorylation PhosphoSitePlus
S2708 Phosphorylation PhosphoSitePlus
T2712 Phosphorylation PhosphoSitePlus
K2757 Ubiquitination PhosphoSitePlus
S2764 Phosphorylation PhosphoSitePlus
R2779 Methylation PhosphoSitePlus
S2892 Phosphorylation PhosphoSitePlus
K2901 Ubiquitination PhosphoSitePlus
K2930 Acetylation PhosphoSitePlus
S2934 Phosphorylation PhosphoSitePlus
T2938 Phosphorylation PhosphoSitePlus
S2948 Phosphorylation PhosphoSitePlus
S2950 Phosphorylation PhosphoSitePlus
K2967 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 C13 Biomuta DOID:3571 / liver cancer [ cosmic ]
S16 F16 Biomuta DOID:4159 / skin cancer [ cosmic ]
T405 P405 Biomuta DOID:263 / kidney cancer [ cosmic ]
S436 L436 Biomuta DOID:4159 / skin cancer [ cosmic ]
K442 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S459 L459 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ icgc ]
S462 N462 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S489 L489 Biomuta DOID:1324 / lung cancer [ cosmic ]
S534 F534 Biomuta DOID:4159 / skin cancer [ cosmic ]
G551 E551 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
G551 W551 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K667 N667 Biomuta DOID:4159 / skin cancer [ cosmic ]
K667 R667 Biomuta DOID:363 / uterine cancer [ icgc ]
T796 N796 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
C807 R807 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S930 L930 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1104 Y1104 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1120 A1120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1120 I1120 Biomuta DOID:263 / kidney cancer [ cosmic ]
T1173 A1173 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1177 F1177 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1199 C1199 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1210 Y1210 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1215 I1215 Biomuta [ cosmic ]
S1347 F1347 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1355 H1355 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1402 N1402 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1674 L1674 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1789 F1789 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1813 C1813 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1862 N1862 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1885 T1885 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C1976 F1976 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S2074 Y2074 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
S2382 N2382 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2443 T2443 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T2654 M2654 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
R2779 K2779 Biomuta DOID:4159 / skin cancer [ cosmic ]
R2779 M2779 Biomuta DOID:9256 / colorectal cancer [ cosmic ]