iPTMnet Report for P42704 (LRPPRC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42704 / LPPRC_HUMAN
Protein Name Leucine-rich PPR motif-containing protein, mitochondrial precursor
Gene Name Name: LRPPRC
Synonyms:LRP130;
Organism Homo sapiens (Human)

PRO ID PR:P42704
DAG View
PRO Name leucine-rich PPR motif-containing protein, mitochondrial (human)
Definition A leucine-rich PPR motif-containing protein, mitochondrial that is encoded in the genome of human.
Short Label hLRPPRC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42704 (LRPPRC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
K107 Acetylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T112 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...30379171, 34725712, 26853435, 33214551, 30620550, 35083852, 32870666, 32119511, 28510447
R128 Methylation PhosphoSitePlus
C130 S-Nitrosylation dbSNO 26338901
K138 Acetylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus   UniProt 19608861
K155 Ubiquitination PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K187 Acetylation PhosphoSitePlus   UniProt 19608861
R197 Methylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K292 Acetylation PhosphoSitePlus   UniProt 19608861
Y320 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
K396 Acetylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
R605 Methylation PhosphoSitePlus
Y607 Phosphorylation PhosphoSitePlus
K613 Acetylation PhosphoSitePlus   UniProt 19608861
K613 Ubiquitination PhosphoSitePlus
K617 Sumoylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
Y623 Phosphorylation PhosphoSitePlus
Y633 Phosphorylation PhosphoSitePlus
K649 Acetylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
T660 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
K726 Acetylation PhosphoSitePlus   UniProt 19608861
R739 Methylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
K750 Acetylation PhosphoSitePlus   UniProt 19608861
Y751 Phosphorylation PhosphoSitePlus
K763 Acetylation PhosphoSitePlus
K777 Acetylation PhosphoSitePlus
T822 Phosphorylation IEDB 32387766
K851 Acetylation PhosphoSitePlus
K864 Acetylation PhosphoSitePlus
K868 Acetylation PhosphoSitePlus
S882 Phosphorylation HPRD 17322306
N903 Phosphorylation HPRD 17322306
T913 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
R929 Methylation PhosphoSitePlus
C930 S-Nitrosylation dbSNO 20140087, 22178444
Y958 Phosphorylation PhosphoSitePlus
K980 Ubiquitination PhosphoSitePlus
Y1016 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1029 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1031 Phosphorylation PhosphoSitePlus
Y1052 Phosphorylation PhosphoSitePlus
Y1070 Phosphorylation PhosphoSitePlus
Y1082 Phosphorylation PhosphoSitePlus
T1084 Phosphorylation PhosphoSitePlus
K1098 Ubiquitination PhosphoSitePlus
T1113 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...30379171, 34725712, 26853435, 33214551, 30620550, 35083852, 32870666, 32119511, 28510447
T1136 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1138 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1163 Ubiquitination PhosphoSitePlus
S1171 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1175 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1215 Phosphorylation PhosphoSitePlus
Y1220 Phosphorylation PhosphoSitePlus
K1224 Acetylation PhosphoSitePlus
Y1251 Phosphorylation PhosphoSitePlus
C1277 S-Nitrosylation dbSNO 26338901
S1306 Phosphorylation PhosphoSitePlus
K1317 Acetylation PhosphoSitePlus
Y1321 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation PhosphoSitePlus
S1327 Phosphorylation PhosphoSitePlus
K1332 Acetylation PhosphoSitePlus
Y1341 Phosphorylation PhosphoSitePlus
T1345 Phosphorylation PhosphoSitePlus
K1350 Ubiquitination PhosphoSitePlus
Y1382 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 F23 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S75 Y75 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S80 F80 Biomuta DOID:4159 / skin cancer [ cosmic ]
T112 I112 Biomuta DOID:1319 / brain cancer [ icgc ]
R128 C128 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R128 H128 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y320 H320 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S536 L536 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S536 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K617 N617 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K649 N649 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S661 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R739 C739 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N903 Y903 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N903 H903 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R929 K929 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K980 T980 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1025 C1025 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1026 L1026 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1070 H1070 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y1070 C1070 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1113 M1113 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1113 A1113 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T1113 R1113 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1171 F1171 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1215 H1215 Biomuta DOID:363 / uterine cancer [ icgc ]
S1306 P1306 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1317 N1317 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1317 R1317 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1323 Y1323 Biomuta DOID:363 / uterine cancer [ icgc ]