Protein Information

Cytoscape View


UniProt AC / UniProt ID P42702 / LIFR_HUMAN
Protein Name Leukemia inhibitory factor receptor precursor
Gene Name Name: LIFR
Organism Homo sapiens (Human)

PRO ID PR:P42702
DAG View
PRO Name leukemia inhibitory factor receptor (human)
Definition A leukemia inhibitory factor receptor that is encoded in the genome of human.
Short Label hLIFR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42702 (LIFR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N131 N-Glycosylation UniProt 18775332
K179 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
N303 N-Glycosylation UniProt 18775332
Y369 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
N407 N-Glycosylation UniProt 18775332
N426 N-Glycosylation UniProt 18775332
S490 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K610 Acetylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
Y759 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
K804 Ubiquitination PhosphoSitePlus
Y807 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
K880 Acetylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K886 Acetylation PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
K896 Acetylation PhosphoSitePlus
T904 Phosphorylation PhosphoSitePlus
S927 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y974 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 7777512
S1047 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
S1077 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T530 Phosphorylation HPRD 20068231
T531 Phosphorylation HPRD 20068231
S534 Phosphorylation HPRD 20068231
Y807 Phosphorylation HPRD 18452278
S927 Phosphorylation HPRD 18669648
S1044 Phosphorylation P28482 (MAPK1) HPRD 7777512
S1077 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K253 N253 Biomuta DOID:363 / uterine cancer [ tcga ]
K253 M253 Biomuta DOID:1324 / lung cancer [ cosmic ]
S490 * Biomuta DOID:1324 / lung cancer [ tcga ]
Y492 C492 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S665 Y665 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S887 N887 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y974 S974 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1044 Y1044 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1047 F1047 Biomuta DOID:1909 / melanoma [ tcga ]