iPTMnet Report for P42694 (HELZ)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42694 / HELZ_HUMAN
Protein Name Probable helicase with zinc finger domain
Gene Name Name: HELZ
Synonyms:DRHC,KIAA0054;
Organism Homo sapiens (Human)

PRO ID PR:P42694
DAG View
PRO Name probable helicase with zinc finger domain (human)
Definition A probable helicase with zinc finger domain that is encoded in the genome of human.
Short Label hHELZ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42694 (HELZ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus   UniProt 23186163
K251 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
Y391 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
S489 Phosphorylation IEDB 32387766
K512 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
T563 O-Glycosylation GlyGen 30379171, 31492838, 34019948, ...35254053
K564 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
T655 Phosphorylation IEDB 32387766
C802 Methylation IEDB 31844290
S888 Phosphorylation PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
S973 O-Glycosylation GlyGen 30379171, 31492838, 34019948, ...35254053
S973 Phosphorylation PhosphoSitePlus
K986 Ubiquitination PhosphoSitePlus
T1007 Phosphorylation PhosphoSitePlus
K1032 Ubiquitination PhosphoSitePlus
T1081 Phosphorylation PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
K1096 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
R1160 Methylation PhosphoSitePlus
Y1162 Phosphorylation PhosphoSitePlus
T1163 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1176 Methylation PhosphoSitePlus
S1177 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S1179 Phosphorylation PhosphoSitePlus
R1219 Methylation PhosphoSitePlus
R1245 Methylation PhosphoSitePlus   UniProt 24129315
S1247 Phosphorylation PhosphoSitePlus
T1260 O-Glycosylation GlyGen 30379171, 31492838, 34019948, ...35254053
K1281 Ubiquitination PhosphoSitePlus
K1293 Ubiquitination PhosphoSitePlus
T1296 Phosphorylation PhosphoSitePlus
S1311 Phosphorylation PhosphoSitePlus
S1317 Phosphorylation PhosphoSitePlus
R1340 Methylation PhosphoSitePlus
Y1353 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
S1442 Phosphorylation PhosphoSitePlus
S1463 Phosphorylation PhosphoSitePlus
S1477 Phosphorylation PhosphoSitePlus
K1560 Ubiquitination PhosphoSitePlus
Y1573 Phosphorylation PhosphoSitePlus
S1584 Phosphorylation PhosphoSitePlus
S1614 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S1620 Phosphorylation PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1660 Phosphorylation PhosphoSitePlus
T1736 Phosphorylation PhosphoSitePlus
S1738 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S1739 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1740 Phosphorylation PhosphoSitePlus
S1741 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1744 Phosphorylation PhosphoSitePlus
Y1758 Phosphorylation PhosphoSitePlus
S1763 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1764 Phosphorylation PhosphoSitePlus
S1765 Phosphorylation PhosphoSitePlus
S1766 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1775 Phosphorylation PhosphoSitePlus
T1776 Phosphorylation PhosphoSitePlus
S1780 Phosphorylation PhosphoSitePlus
Y1813 Phosphorylation PhosphoSitePlus
K1838 Ubiquitination PhosphoSitePlus
S1878 Phosphorylation PhosphoSitePlus
S1882 O-Glycosylation GlyGen 30379171, 31492838, 34019948, ...35254053
S1883 Phosphorylation PhosphoSitePlus
S1886 Phosphorylation PhosphoSitePlus
K1891 Ubiquitination PhosphoSitePlus
S1898 Phosphorylation PhosphoSitePlus
S1934 Phosphorylation PhosphoSitePlus
Y1938 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T113 Phosphorylation HPRD 20068231
T421 Phosphorylation HPRD 20068231
S1177 Phosphorylation HPRD 15302935
T1284 Phosphorylation HPRD 20068231
S1311 Phosphorylation HPRD 17081983
Y1353 Phosphorylation HPRD 16497976
S1739 Phosphorylation HPRD 18669648
S1741 Phosphorylation HPRD 18669648
S1763 Phosphorylation HPRD 18669648
S1883 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 T56 Biomuta DOID:363 / uterine cancer [ icgc ]
K56 N56 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T113 S113 Biomuta DOID:4159 / skin cancer [ cosmic ]
S246 L246 Biomuta DOID:4159 / skin cancer [ cosmic ]
S277 F277 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
K404 T404 Biomuta DOID:363 / uterine cancer [ icgc ]
K449 N449 Biomuta DOID:363 / uterine cancer [ icgc ]
Y456 C456 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K543 M543 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T563 R563 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T563 S563 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S629 N629 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
C802 R802 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1007 K1007 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1095 N1095 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1096 N1096 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R1160 K1160 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1160 T1160 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1245 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1247 Y1247 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1311 * Biomuta DOID:1612 / breast cancer [ cosmic ]
R1340 K1340 Biomuta DOID:363 / uterine cancer [ icgc ]
R1340 T1340 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y1353 F1353 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1614 R1614 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S1764 Y1764 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1883 I1883 Biomuta DOID:9256 / colorectal cancer [ cosmic ]