Protein Information

Cytoscape View


UniProt AC / UniProt ID P42684 / ABL2_HUMAN
Protein Name Tyrosine-protein kinase ABL2
Gene Name Name: ABL2
Synonyms:ABLL,ARG;
Organism Homo sapiens (Human)

PRO ID PR:P42684
DAG View
PRO Name tyrosine-protein kinase ABL2 (human)
Definition A tyrosine-protein kinase ABL2 that is encoded in the genome of human.
Short Label hABL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42684 (ABL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R23 Methylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
S71 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S72 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation P09619 (PDGFRB) PhosphoSitePlus 19275932
S159 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation P09619 (PDGFRB) PhosphoSitePlus 19275932
T163 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S200 Phosphorylation phospho.ELM 17081983
S203 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation P00519 (ABL1) , P42684 (ABL2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15735735
Y272 Phosphorylation P42684 (ABL2) , P09619 (PDGFRB) neXtProt   PhosphoSitePlus   UniProt 12748290, 19275932
S275 Phosphorylation PhosphoSitePlus   UniProt 18691976
Y299 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
Y310 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
S311 Phosphorylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation P42684 (ABL2) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18083107, 15735735, 12748290, ...12522270
T440 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
K446 Ubiquitination PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
Y515 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
Y568 Phosphorylation P42684 (ABL2) neXtProt   PhosphoSitePlus   UniProt 12748290
S577 Phosphorylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S620 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S631 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...17192257, 18669648, 24275569, 20068231
S633 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S634 Phosphorylation PhosphoSitePlus
S655 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K659 Acetylation PhosphoSitePlus
T664 Phosphorylation PhosphoSitePlus
K667 Methylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y683 Phosphorylation P42684 (ABL2) neXtProt   UniProt 12748290
Y718 Phosphorylation PhosphoSitePlus   UniProt 19369195
T753 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
S783 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17192257
T784 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K809 Ubiquitination PhosphoSitePlus
T815 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S817 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648, ...17192257
T818 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
S820 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648, ...19690332
T864 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S915 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
S936 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257, 18669648, ...19690332, 20068231
T938 Phosphorylation PhosphoSitePlus
K957 Methylation PhosphoSitePlus
K957 Ubiquitination PhosphoSitePlus
K959 Methylation PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
K981 Acetylation PhosphoSitePlus
T1050 Phosphorylation phospho.ELM 18669648
S1051 Phosphorylation PhosphoSitePlus
S1054 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1057 Methylation PhosphoSitePlus
K1066 Methylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus
T1112 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 20068231
S31 Phosphorylation HPRD 20068231
T68 Phosphorylation HPRD 18691976
S71 Phosphorylation HPRD 18691976
S96 Phosphorylation HPRD 18691976
Y116 Phosphorylation HPRD 18691976
S200 Phosphorylation HPRD 20068231
S203 Phosphorylation HPRD 18691976, 17081983, 20068231
S208 Phosphorylation HPRD 20068231
Y231 Phosphorylation HPRD 18691976
Y272 Phosphorylation HPRD 18691976
S275 Phosphorylation HPRD 18691976
T313 Phosphorylation HPRD 20068231
T438 Phosphorylation HPRD 20068231
T440 Phosphorylation HPRD 20068231
T599 Phosphorylation HPRD 18691976
S602 Phosphorylation HPRD 18691976
S617 Phosphorylation HPRD 18691976
S618 Phosphorylation HPRD 18691976
S620 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19664994
S631 Phosphorylation HPRD 19413330, 18691976, 19651622, ...17322306, 18669648, 20068231
S633 Phosphorylation HPRD 19651622, 18669648, 17081983
S634 Phosphorylation HPRD 17081983
S655 Phosphorylation HPRD 18669648
S671 Phosphorylation HPRD 18691976
Y718 Phosphorylation HPRD 18691976
S781 Phosphorylation HPRD 18691976
S783 Phosphorylation HPRD 19413330, 18669648
T784 Phosphorylation HPRD 18669648
S788 Phosphorylation HPRD 18691976
S789 Phosphorylation HPRD 18691976
T815 Phosphorylation HPRD 18691976, 18669648
S817 Phosphorylation HPRD 19413330, 18691976, 17525332, ...18669648
T818 Phosphorylation HPRD 19413330, 18691976
S820 Phosphorylation HPRD 19413330, 18691976, 17525332, ...18669648
T864 Phosphorylation HPRD 18691976
S915 Phosphorylation HPRD 18691976, 18669648
S936 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 18669648, 20068231
T938 Phosphorylation HPRD 19413330
S968 Phosphorylation HPRD 18691976
T1050 Phosphorylation HPRD 18691976, 18669648
S1054 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y668 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y59 Phosphorylation PhosphoSitePlus


P42684 (ABL2) as PTM Enzyme



Substrate Site Score Source PMID
O00401 (WASL) Y256 neXtProt 20146487
O14818 (PSMA7) Y153 neXtProt   PhosphoSitePlus   Signor 16678104
O15304 (SIVA1) Y34 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11278261
P01112 (HRAS) Y137 PhosphoSitePlus 25999467
P04040 (CAT) Y231 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12950161, 12777400
P04040 (CAT) Y386 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12950161, 12777400
P05556 (ITGB1) Y783 PhosphoSitePlus 25694433
P07203-1 (GPX1) Y98 HPRD   neXtProt   PhosphoSitePlus   Signor 12893824
P09619 (PDGFRB) Y686 PhosphoSitePlus 19275932
P10636-8 (MAPT) Y197 PhosphoSitePlus 20110615
P10636-8 (MAPT) Y310 PhosphoSitePlus 20110615
P10636-8 (MAPT) Y394 PhosphoSitePlus 20110615
P17676 (CEBPB) Y78 PhosphoSitePlus   Signor 19563810
P17931 (LGALS3) Y79 PhosphoSitePlus   Signor 20150913
P17931 (LGALS3) Y118 PhosphoSitePlus   Signor 20150913
P42684 (ABL2) Y261 neXtProt   PhosphoSitePlus   Signor   UniProt 15735735
P42684 (ABL2) Y272 neXtProt   UniProt 12748290
P42684 (ABL2) Y439 neXtProt   PhosphoSitePlus   UniProt 15735735, 12748290
P42684 (ABL2) Y568 neXtProt   UniProt 12748290
P42684 (ABL2) Y683 neXtProt   UniProt 12748290
P46108 (CRK) Y221 HPRD   neXtProt   PhosphoSitePlus 11956190, 17016520, 9642287, ...8875975, 9480911, 12198159, 8194526, 20068231
Q13671 (RIN1) Y36 neXtProt 15886098
Q14247 (CTTN) Y421 neXtProt 17306540
Q14247 (CTTN) Y470 neXtProt 17306540
Q14247 (CTTN) Y486 neXtProt 17306540
Q9NRY4 (ARHGAP35) Y1105 neXtProt 15084284


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y1172 P42684 (ABL2) unknown eFIP 16273093
Phosphorylation P04626 (ERBB2) Y1139 P42684 (ABL2) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1224 P42684 (ABL2) unknown eFIP 16273093
Phosphorylation P36888 (FLT3) Y726 P42684 (ABL2) unknown eFIP 28086240
Phosphorylation Q15303 (ERBB4) Y1258 P42684 (ABL2) unknown eFIP 16273093
Phosphorylation Q8IZP0 (ABI1) Y421 P42684 (ABL2) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y139 C139 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S159 N159 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T163 N163 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S275 F275 Biomuta DOID:4362 / cervical cancer [ tcga ]
Y299 C299 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y303 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y310 C310 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K446 N446 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K578 N578 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K667 R667 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S671 F671 Biomuta DOID:1909 / melanoma [ tcga ]
T753 A753 Biomuta DOID:1612 / breast cancer [ cosmic ]
S788 T788 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S866 P866 Biomuta DOID:3070 / malignant glioma [ tcga ]
S866 Y866 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T938 N938 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S968 F968 Biomuta DOID:1909 / melanoma [ icgc, tcga ]