iPTMnet Report for P42680 (TEC)
Protein Information
| UniProt AC / UniProt ID | P42680 / TEC_HUMAN |
| Protein Name | Tyrosine-protein kinase Tec |
| Gene Name | Name: TEC Synonyms:PSCTK4; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P42680 |
| PRO Name | tyrosine-protein kinase Tec (human) |
| Definition | A tyrosine-protein kinase Tec that is encoded in the genome of human. |
| Short Label | hTEC |
| Category | organism-gene |
DAG ViewP42680 (TEC) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K51 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K60 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T88 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y90 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y120 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S129 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y130 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K155 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y188 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y206 | Phosphorylation | Q06187 (BTK) , Q08881 (ITK) , P42680 (TEC) | score4 | HPRD neXtProt phospho.ELM PRO PhosphoSitePlus Signor UniProt | 19369195, 12573241 | |
| Y223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y228 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| Y233 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y281 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y343 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y360 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y519 | Phosphorylation | P42680 (TEC) , O60674 (JAK2) , P07948 (LYN) | score4 | neXtProt PRO PhosphoSitePlus UniProt | 19690332, 9473212 | |
| T520 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K526 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T618 | Phosphorylation | score1 | PhosphoSitePlus |
P42680 (TEC) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P09038 (FGF2) | Y215 | score2 | neXtProt | 20230531 | |
| P09038 (FGF2) | Y257 | score2 | neXtProt | 20230531 | |
| P16885 (PLCG2) | Y753 | score2 | neXtProt | 15184383 | |
| P16885 (PLCG2) | Y759 | score2 | neXtProt | 15184383 | |
| P42680 (TEC) | Y206 | score3 | HPRD phospho.ELM PhosphoSitePlus Signor UniProt | 12573241 | |
| P42680 (TEC) | Y519 | score1 | UniProt | 19690332 | |
| P51813 (BMX) | Y216 | score3 | HPRD PhosphoSitePlus Signor | 12573241 | |
| P51813 (BMX) | Y224 | score3 | HPRD phospho.ELM Signor | 12573241 | |
| Q06187 (BTK) | Y223 | score4 | HPRD PhosphoSitePlus Signor | 8630736, 8629002, 11598012, ... | |
| Q08881 (ITK) | Y180 | score2 | PhosphoSitePlus | 12573241 | |
| Q13322 (GRB10) | Y67 | score2 | neXtProt | 9753425 | |
| Q99952 (PTPN18) | Y281 | score3 | HPRD PhosphoSitePlus | 14679216 | |
| Q99952 (PTPN18) | Y303 | score3 | HPRD PhosphoSitePlus | 14679216 | |
| Q99952-1 (PTPN18) | Y354 | score3 | HPRD PhosphoSitePlus | 14679216 | |
| Q99952 (PTPN18) | Y389 | score2 | PhosphoSitePlus | 14679216 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049416 (hTEC/Phos:1) | pY206,pY519 | PRO | |||
| PR:000049417 (hTEC/Phos:2) | pY519 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K60 | T60 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| Y360 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y519 | C519 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |
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