iPTMnet Report P42679 MATK

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P42679 / MATK_HUMAN
Protein Name	Megakaryocyte-associated tyrosine-protein kinase
Gene Name	Name: MATK Synonyms:CTK,HYL;
Organism	Homo sapiens (Human)

PRO ID	PR:P42679 DAG View
PRO Name	megakaryocyte-associated tyrosine-protein kinase (human)
Definition	A megakaryocyte-associated tyrosine-protein kinase that is encoded in the genome of human.
Short Label	hMATK
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P42679 (MATK) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	R4	Methylation		score1	PhosphoSitePlus
	R11	Methylation		score1	PhosphoSitePlus
	S26	Phosphorylation		score1	PhosphoSitePlus
	R31	Methylation		score1	PhosphoSitePlus
	T76	Phosphorylation		score1	PhosphoSitePlus
	S85	Phosphorylation		score1	PhosphoSitePlus
	Y87	Phosphorylation		score1	PhosphoSitePlus
	K116	Ubiquitination		score1	PhosphoSitePlus
	C204	Methylation		score1	IEDB	31844290
	S308	Phosphorylation		score1	PhosphoSitePlus
	T500	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
	S501	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 17525332, 15302935, ...18669648
	S504	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17525332

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T500	Phosphorylation		score0	HPRD	18669648
	S501	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...15302935
	S504	Phosphorylation		score0	HPRD	17525332

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T18	Phosphorylation		score1	PhosphoSitePlus
	S27	Phosphorylation		score1	PhosphoSitePlus
	T501	Phosphorylation		score0	HPRD	18669648
	S502	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...15302935
	S505	Phosphorylation		score0	HPRD	17525332

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T459	Phosphorylation		score0	HPRD	18669648
	S460	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...15302935
	S463	Phosphorylation		score0	HPRD	17525332

P42679 (MATK) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P06239 (LCK)	Y505	score3	neXtProt	8197166, 7511815
	P07948 (LYN)	Y508	score4	HPRD neXtProt PhosphoSitePlus	19901323, 18691976, 8612628, ...18452278, 19651622, 18669648, 14985335, 9171348, 20068231, 16497976
	P08631 (HCK)	Y522	score2	neXtProt	14985335
	P12931 (SRC)	Y530	score3	neXtProt	12767803, 7530249, 14985335
	P78324 (SIRPA)	Y429	score4	neXtProt PhosphoSitePlus	17999719, 21799000
	P78324 (SIRPA)	Y453	score4	neXtProt PhosphoSitePlus	17999719, 21799000
	P78324 (SIRPA)	Y470	score2	neXtProt	17999719
	P78324 (SIRPA)	Y496	score2	neXtProt	17999719

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
R4	Q4	Biomuta		DOID:5041 / esophageal cancer [ cosmic ]
S26	R26	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]
S27	R27	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]
S460	L460	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S501	L501	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S502	L502	Biomuta		DOID:4159 / skin cancer [ cosmic ]