iPTMnet Report for P42575 (CASP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42575 / CASP2_HUMAN
Protein Name Caspase-2 precursor
Gene Name Name: CASP2
Synonyms:ICH1,NEDD2;
Organism Homo sapiens (Human)

PRO ID PR:P42575
DAG View
PRO Name caspase-2 (human)
Definition A caspase-2 that is encoded in the genome of human.
Short Label hCASP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42575 (CASP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S8 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
R22 Methylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K77 Sumoylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
R107 Methylation PhosphoSitePlus
S139 Phosphorylation P78527 (PRKDC) PhosphoSitePlus   Signor 19203584
Y151 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S157 Phosphorylation P68400 (CSNK2A1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16193064, 23186163, 33011746
T160 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S220 Phosphorylation RLIMS-P 33011746
K254 Ubiquitination PhosphoSitePlus
C270 Methylation IEDB 31844290
S307 Phosphorylation RLIMS-P 33011746
K335 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21406692, 19730412, 33011746
Y368 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
T380 Phosphorylation RLIMS-P 33011746
S384 Phosphorylation RLIMS-P 32811973, 33011746
K409 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
C436 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S157 Phosphorylation HPRD 19651622
T158 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 F8 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K93 E93 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y151 F151 Biomuta DOID:1324 / lung cancer [ cosmic ]
K153 N153 Biomuta DOID:1324 / lung cancer [ cosmic ]
S157 L157 Biomuta DOID:363 / uterine cancer [ icgc ]
S164 F164 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K335 N335 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S340 F340 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T380 I380 Biomuta DOID:4159 / skin cancer [ cosmic ]
K415 N415 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y420 C420 Biomuta DOID:9256 / colorectal cancer [ cosmic ]