Protein Information

Cytoscape View

UniProt AC / UniProt ID P42574 / CASP3_HUMAN
Protein Name Caspase-3 precursor
Gene Name Name: CASP3
Organism Homo sapiens (Human)

PRO ID PR:P42574
DAG View
PRO Name caspase-3 (human)
Definition A caspase-3 that is encoded in the genome of human.
Short Label hCASP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P42574 (CASP3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
T4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15345747, 23186163
S29 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S150 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14970175
T152 Phosphorylation PhosphoSitePlus
C163 S-Nitrosylation dbSNO 22178444, 9034139
T174 Phosphorylation RLIMS-P 23599180
S176 Phosphorylation RLIMS-P 23599180
K210 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
T270 Phosphorylation HPRD 18452278

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 A12 Biomuta DOID:363 / uterine cancer [ tcga ]
S24 G24 Biomuta DOID:3571 / liver cancer [ tcga ]
T67 K67 Biomuta DOID:3571 / liver cancer [ icgc ]
T174 K174 Biomuta DOID:3571 / liver cancer [ icgc ]
S249 F249 Biomuta DOID:1909 / melanoma [ tcga ]