Protein Information

Cytoscape View


UniProt AC / UniProt ID P42566 / EPS15_HUMAN
Protein Name Epidermal growth factor receptor substrate 15
Gene Name Name: EPS15
Synonyms:AF1P;
Organism Homo sapiens (Human)

PRO ID PR:P42566
DAG View
PRO Name epidermal growth factor receptor substrate 15 (human)
Definition An epidermal growth factor receptor substrate 15 that is encoded in the genome of human.
Short Label hEPS15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42566 (EPS15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S8 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus   UniProt 19690332
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S221 Phosphorylation PhosphoSitePlus
K227 Methylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K234 Methylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 19690332
S324 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 24275569, ...18088087, 19690332, 20068231
K333 Ubiquitination PhosphoSitePlus
K357 Acetylation PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus   UniProt 20068231
S470 Phosphorylation PhosphoSitePlus   UniProt 20068231
K472 Ubiquitination PhosphoSitePlus
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17525332
K495 Ubiquitination PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S562 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S563 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S587 Phosphorylation PhosphoSitePlus
S595 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S605 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus   UniProt 23186163
K754 Ubiquitination PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
T777 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163, 24275569
T779 Phosphorylation PhosphoSitePlus
K788 Acetylation PhosphoSitePlus
K788 Ubiquitination PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
K793 Ubiquitination PhosphoSitePlus
S796 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 18088087, 24269888, ...28428548, 24275569, 23186163, 28947773, 20068231
K801 Ubiquitination PhosphoSitePlus
S814 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 18088087, 19690332, 20068231
K816 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
Y849 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15951569, 10953014, 24269888, ...19690332
S851 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K890 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S107 Phosphorylation HPRD 20058876
S108 Phosphorylation HPRD 20058876
S116 Phosphorylation HPRD 20068231
S140 Phosphorylation HPRD 18669648
S323 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664995, 18669648, 20068231
S324 Phosphorylation HPRD 19413330, 18691976, 18088087, ...19664995, 17322306, 20068231
S467 Phosphorylation HPRD 20068231
S470 Phosphorylation HPRD 20068231
S485 Phosphorylation HPRD 17525332, 18669648, 20068231
S562 Phosphorylation HPRD 19651622, 18669648
S595 Phosphorylation HPRD 18669648
T777 Phosphorylation HPRD 18088087
S790 Phosphorylation HPRD 19651622, 20068231
S796 Phosphorylation HPRD 19413330, 17322306, 18088087, ...18767875, 19664994, 19651622, 20058876, 20166139, 20068231
S814 Phosphorylation HPRD 18691976, 18088087, 18767875, ...19664994, 19651622, 17322306, 18669648, 20058876, 20068231
Y849 Phosphorylation P00533 (EGFR) HPRD 17016520, 10953014, 17389395


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047314 (hEPS15/Phos:1) pY849 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 C8 Biomuta DOID:263 / kidney cancer [ cosmic ]
S116 C116 Biomuta DOID:1909 / melanoma [ cosmic ]
K234 T234 Biomuta DOID:363 / uterine cancer [ tcga ]
S323 P323 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K333 N333 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
K333 R333 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
K413 N413 Biomuta DOID:4362 / cervical cancer [ tcga ]
S435 C435 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S455 R455 Biomuta DOID:3571 / liver cancer [ icgc ]
K495 T495 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S558 Y558 Biomuta DOID:3571 / liver cancer [ icgc ]
S587 C587 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S606 G606 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S606 I606 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K774 N774 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T777 N777 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K788 N788 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K793 N793 Biomuta DOID:363 / uterine cancer [ tcga ]
S796 F796 Biomuta DOID:363 / uterine cancer [ tcga ]
S796 Y796 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]