iPTMnet Report for P42336 (PIK3CA)
Protein Information
| UniProt AC / UniProt ID | P42336 / PK3CA_HUMAN |
| Protein Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| Gene Name | Name: PIK3CA |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P42336 |
| PRO Name | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (human) |
| Definition | A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of human. |
| Short Label | hPIK3CA |
| Category | organism-gene |
DAG ViewP42336 (PIK3CA) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K148 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S306 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S312 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T313 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y317 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S332 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y355 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y361 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S507 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y508 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S509 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K532 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y584 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S681 | Phosphorylation | score1 | IEDB | 30784271 | ||
| Y698 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K863 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S874 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T876 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T957 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K973 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1030 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y1038 | Phosphorylation | score1 | PhosphoSitePlus |
P42336 (PIK3CA) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P09493 (TPM1) | S61 | score3 | phospho.ELM PhosphoSitePlus | 16094730 | |
| P23443 (RPS6KB1) | T252 | score2 | PhosphoSitePlus | 11684675 | |
| P23443-1 (RPS6KB1) | T390 | score2 | HPRD | 18669648, 11279232, 20068231 | |
| P23443 (RPS6KB1) | T412 | score2 | PhosphoSitePlus | 11684675 | |
| P27986 (PIK3R1) | S608 | score4 | neXtProt phospho.ELM PhosphoSitePlus | 9446654, 23270540, 14729945 | |
| P32927 (CSF2RB) | S585 | score2 | neXtProt | 23526884 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P27986 (PIK3R1) | S608 | P42336 (PIK3CA) | decreased_association | eFIP | 14729945 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K184 | E184 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y246 | N246 | Biomuta | DOID:10534 / stomach cancer [ icgc ] | |
| S509 | F509 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| K1030 | E1030 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| Y1038 | C1038 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
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