iPTMnet Report for P42330 (AKR1C3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42330 / AK1C3_HUMAN
Protein Name Aldo-keto reductase family 1 member C3
Gene Name Name: AKR1C3
Synonyms:DDH1,HSD17B5,KIAA0119,PGFS;
Organism Homo sapiens (Human)

PRO ID PR:P42330
DAG View
PRO Name aldo-keto reductase family 1 member C3 (human)
Definition An aldo-keto reductase family 1 member C3 that is encoded in the genome of human.
Short Label hAKR1C3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42330 (AKR1C3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Sumoylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K39 Methylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K209 Acetylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 N9 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K9 Q9 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S51 F51 Biomuta DOID:363 / uterine cancer [ icgc ]
S67 R67 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T82 N82 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S83 L83 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S129 L129 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K183 R183 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S232 F232 Biomuta DOID:4159 / skin cancer [ cosmic ]
S320 L320 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y323 * Biomuta DOID:263 / kidney cancer [ cosmic ]