iPTMnet Report for P42285 (MTREX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42285 / MTREX_HUMAN
Protein Name Exosome RNA helicase MTR4
Gene Name Name: MTREX
Synonyms:DOB1;
Organism Homo sapiens (Human)

PRO ID PR:P42285
DAG View
PRO Name exosome RNA helicase MTR4 (human)
Definition An exosome RNA helicase MTR4 that is encoded in the genome of human.
Short Label hMTREX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42285 (MTREX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
S40 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K43 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus   UniProt 19608861
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
C170 Methylation IEDB 31844290
T188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation HPRD   PhosphoSitePlus 20068231
K192 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K396 Acetylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
Y583 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
Y590 Phosphorylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
Y694 Phosphorylation PhosphoSitePlus
K748 Acetylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K792 Acetylation PhosphoSitePlus
K796 Acetylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
C822 Methylation IEDB 31844290
T844 Phosphorylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
C983 Methylation IEDB 31844290
C996 Methylation IEDB 31844290
K1022 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K78 N78 Biomuta DOID:1612 / breast cancer [ cosmic ]
K126 T126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T188 A188 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S189 I189 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K358 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K408 T408 Biomuta DOID:363 / uterine cancer [ cosmic ]
T466 N466 Biomuta DOID:363 / uterine cancer [ icgc ]
S472 F472 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y517 C517 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K768 R768 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C822 R822 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C983 Y983 Biomuta DOID:9256 / colorectal cancer [ cosmic ]