Protein Information

Cytoscape View

UniProt AC / UniProt ID P42262 / GRIA2_HUMAN
Protein Name Glutamate receptor 2 precursor
Gene Name Name: GRIA2
Organism Homo sapiens (Human)

PRO ID PR:P42262
DAG View
PRO Name glutamate receptor 2 (human)
Definition A glutamate receptor 2 that is encoded in the genome of human.
Short Label hGRIA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P42262 (GRIA2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T279 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
N370 N-Glycosylation GlyGen   UniProt 26271046, 19651138
S518 Phosphorylation PhosphoSitePlus
T638 Phosphorylation RLIMS-P 30883902
S863 Phosphorylation RLIMS-P 11640921
Y876 Phosphorylation PhosphoSitePlus   RLIMS-P 15240807, 23431139
S880 Phosphorylation P17252 (PRKCA) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 14534256, 11640921, 11931741, ...18417360, 11466413, 16055064, 26966584, 23431139, 20571220, 11007883, 18945913, 29247190, 11248365, 32052226, 26668821, 19279258, 32729828, 10501226, 12930798, 17460080, 22049330, 18077702
Site PTM Type PTM Enzyme Score Source PMID
S880 Phosphorylation HPRD 16055064
Site PTM Type PTM Enzyme Score Source PMID
S683 Phosphorylation P17252 (PRKCA) HPRD 8848293
S717 Phosphorylation P17252 (PRKCA) HPRD 8848293
T765 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
S880 Phosphorylation P17252 (PRKCA) HPRD 11007883, 10501226, 12805550, ...12058067


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047612 (hGRIA2/SigPep-/Phos:1) pS880 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42262 (GRIA2) S880 Q9Y3R0 (GRIP1) decreased_association eFIP 10501226
Phosphorylation P42262 (GRIA2) S880 Q9Y3R0 (GRIP1) decreased_association eFIP 11007883
Phosphorylation P42262 (GRIA2) S880 Q9NRD5 (PICK1) unknown eFIP 22049330

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y285 C285 Biomuta DOID:363 / uterine cancer [ tcga ]
Y285 * Biomuta DOID:3070 / malignant glioma [ tcga ]
T638 M638 Biomuta DOID:1324 / lung cancer [ tcga ]
S880 I880 Biomuta DOID:3571 / liver cancer [ icgc ]
S880 N880 Biomuta DOID:1909 / melanoma [ tcga ]