iPTMnet Report for P42229 (STAT5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42229 / STA5A_HUMAN
Protein Name Signal transducer and activator of transcription 5A
Gene Name Name: STAT5A
Synonyms:STAT5;
Organism Homo sapiens (Human)

PRO ID PR:P42229
DAG View
PRO Name signal transducer and activator of transcription 5A (human)
Definition A signal transducer and activator of transcription 5a that is encoded in the genome of human.
Short Label hSTAT5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42229 (STAT5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y22 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16497976
T92 O-Glycosylation GlyGen   PhosphoSitePlus 16408927, 14597631, 28074064
T92 Phosphorylation PhosphoSitePlus   RLIMS-P 28074064
C101 Methylation IEDB 31844290
Y114 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus   UniProt 23186163
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S193 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K207 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
K256 Sumoylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K384 Sumoylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S473 Phosphorylation RLIMS-P 26919105
K516 Sumoylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
S552 Phosphorylation RLIMS-P 33036254
K586 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
T648 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 24836440
Y683 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 24836440, 12237455
T684 Phosphorylation IntAct 12237455
K689 Ubiquitination PhosphoSitePlus
Y694 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9813040, 23814025, 11413148, ...23332799, 31817106, 24416160, 18250158, 26815406, 20498019, 11641791, 10508857, 15863494, 10849428, 15939795, 31371410, 12089361, 25885255, 9382798, 17190839, 23440042, 21625473, 18063684, 34188118, 26928938, 9573010, 33669259, 16464493, 28676702, 31932645, 7744007, 15536163, 24836440, 15534001, 20667852, 32041350, 9343435, 30472492, 28422713, 14597631, 21205088, 11046040, 9837784, 7925280, 19088846, 12456798, 10358079, 35751654, 16765629, 23383227, 32633727, 12529425, 28798028, 21135090, 17081983, 27769062, 33763079, 25568664, 22271575, 24728078, 31053703, 9880255, 19949423, 18083107, 31205408, 21772264, 22926520, 23353780, 16139998, 21716071, 25781955, 28005077
Y694 Phosphorylation O60674 (JAK2) phospho.ELM   PhosphoSitePlus 11641791, 16464493
Y694 Phosphorylation P06213 (INSR) neXtProt 12456798
Y694 Phosphorylation P06239 (LCK) PhosphoSitePlus 10849428
Y694 Phosphorylation P07948 (LYN) neXtProt   phospho.ELM 9573010, 11641791
Y694 Phosphorylation P08631 (HCK) PhosphoSitePlus 25885255
Y694 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 11641791
Y694 Phosphorylation P43405 (SYK) PhosphoSitePlus 10849428
Y694 Phosphorylation P52333 (JAK3) neXtProt   PhosphoSitePlus   Signor 19088846, 9382798, 10849428, ...18250158
Y694 Phosphorylation Q06187 (BTK) neXtProt 11413148
Y694 Phosphorylation Q13882 (PTK6) neXtProt 21205088
K696 Acetylation PhosphoSitePlus
K696 Sumoylation PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
K700 Acetylation PhosphoSitePlus
K700 Sumoylation PhosphoSitePlus
Y720 Phosphorylation RLIMS-P 26413425
S726 Phosphorylation PhosphoSitePlus   RLIMS-P 12529425, 28422713, 31932645, ...34188118, 11046040, 21716071
T757 Phosphorylation RLIMS-P 11133982
S774 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
S780 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12529425, 23186163, 34188118, ...10194762, 12732616, 31932645
S780 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 10194762
S780 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor 10194762
S780 Phosphorylation Q13153 (PAK1) neXtProt 12732616
S792 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y90 Phosphorylation HPRD 16497976
S193 Phosphorylation HPRD 19651622, 18669648, 20068231
Y694 Phosphorylation HPRD 17016520, 17389395, 11413148, ...7925280, 8617237, 16497976
Y694 Phosphorylation O60674 (JAK2) HPRD 17016520, 17389395, 11413148, ...7925280, 8617237, 16497976
Y694 Phosphorylation Q06187 (BTK) HPRD 17016520, 17389395, 11413148, ...7925280, 8617237, 16497976
S726 Phosphorylation HPRD 12091337
S780 Phosphorylation HPRD 12091337


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K70 N70 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S128 F128 Biomuta [ cosmic ]
K163 N163 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S193 R193 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K336 R336 Biomuta DOID:263 / kidney cancer [ cosmic ]
K359 N359 Biomuta DOID:1612 / breast cancer [ cosmic ]
S375 N375 Biomuta DOID:4159 / skin cancer [ cosmic ]
K384 R384 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T648 M648 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y682 C682 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y683 S683 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y683 H683 Biomuta DOID:4159 / skin cancer [ cosmic ]
S774 T774 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S777 Y777 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S780 L780 Biomuta DOID:10283 / prostate cancer [ cosmic ]