iPTMnet Report for P42227 (Stat3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42227 / STAT3_MOUSE
Protein Name Signal transducer and activator of transcription 3
Gene Name Name: Stat3
Synonyms:Aprf;
Organism Mus musculus (Mouse)

PRO ID PR:P42227
DAG View
PRO Name signal transducer and activator of transcription 3 (mouse)
Definition A signal transducer and activator of transcription 3 that is encoded in the genome of mouse.
Short Label mSTAT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42227 (Stat3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R31 Methylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K383 Acetylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
K685 Acetylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26919063, 26789017, 26923837, ...15705584, 26491103, 32041943, 29016674, 31601900, 32183406, 31885639, 31115390, 31474988, 30993885, 25868979, 31066230, 33828598, 17683579, 20959490, 24130924, 28453725, 22614008, 25432886, 19284588, 24376586, 28642132, 17401459, 12637586, 19299019, 20107108, 19071214, 29047406, 31176371, 33332446, 23114963, 22824293, 31770366, 22348200, 32483468, 23750710, 23811270, 28870220, 28625915, 28415722, 15923602, 33539470, 27524110, 23118721, 21617181, 26075036, 32308756, 24655440, 32064174, 25147435, 23842188, 28101184, 24416452, 24093616, 32286285, 11278353, 32627301, 23979021, 29262585, 31072360, 21809363, 12049654, 10896772, 19696070, 17283176, 30542122, 28178326, 26260587, 33500396, 23216800, 11553624, 27050378, 25788267, 24449804, 27050391, 32694788, 23434585, 27215660, 28849098, 24606867, 26823495, 30818341, 24789104, 26556875, 30070632, 26512963, 28750090, 9531474, 28162277, 20151299, 32025217, 21354226, 25200186, 26633714, 22992748, 31315045, 26910359, 31862381, 26398946, 15007380, 32312954, 24619572, 20300524, 32467752, 28320842, 27306323, 26575024, 26413468, 27021905, 30333721, 30791634, 27829437, 35806005, 26775702, 20484139, 25741592, 24286865, 27795451, 18158318, 32871210, 32527985, 25581158, 30364083, 29238104, 35732128, 26892021, 26911838, 23593315, 18025205, 23530005, 31924750, 29074644, 27840174, 28642362, 27641629, 30143645, 32732870, 28848431, 31699972, 28554144, 23589566, 28508871, 25337545, 23533666, 22911886, 33803551, 26061710, 25275304, 26612419, 30266298, 36010614, 28106119, 24132923, 27384491, 32210977, 31049028, 23693126, 31683879, 26830149, 28383060, 29254203, 28383063, 28542400, 24819473, 24508558, 27537526, 25331984, 11294897, 27779705, 29079839, 30224299, 33428604, 30918582, 25880134, 22907754, 21997191, 29867489, 29743632, 30353167, 28386145, 24152426, 33758164, 23531921, 25512545, 22511936, 24744866, 30559339, 29729074, 18500982, 31073117, 26764350, 23166634, 27724964, 28596565, 16417589, 30108694, 30953001, 21518725, 28706517, 26848037, 32999332, 33361763, 31819365, 22844518, 27582544, 12684046, 18794085, 33985537, 26573296, 25025494, 27102301, 33413536, 28400195, 26247733, 30870482, 31506552, 23109669, 21486047, 23416975, 33298620, 26826115, 29202102, 24850910, 30528455, 33082817, 18034455, 31292446, 25216522, 24323291, 28338101, 31803051, 33287358, 27589562, 29263930, 32943679, 22206672, 27430527, 21056997, 18489773, 33672392, 33859760, 21810913, 24410832, 15328362, 35983049, 24806510, 27886188, 26317647, 28445952, 33824326, 15465816, 18403479, 24682898, 31552035, 16377083, 29284516, 29507229, 30606233, 31474764, 15781265, 28273928, 18795895, 27217982, 28066259, 22074622, 24223854, 35411090, 35585990, 24302476, 15936723, 11591769, 24260381, 29458077, 27449092, 35917766, 25412315, 29797458, 33294147, 24887420, 33040485, 30988739, 31581535, 31217524, 28938568, 26380299, 27706259, 26378915, 25611086, 27080032, 29304053, 30107531, 27835873, 31780948, 28903339, 28591717, 29382715, 30741923, 24681959, 11830592, 33491667, 31161238, 26444028, 30899259, 30648776
Y705 Phosphorylation P05480 (Src) PhosphoSitePlus 11278353
Y705 Phosphorylation P52332 (Jak1) Signor 26260587
Y705 Phosphorylation Q62120 (Jak2) PhosphoSitePlus 11278353
K707 Acetylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
K709 Acetylation PhosphoSitePlus
T714 O-Glycosylation GlyGen 31616917, 28528544, 32848054, ...32782141, 36852467, 18519567, 26866564, 25153642, 28135057, 28280036, 22517741, 22645316, 24788674, 35822049, 37058110
T714 Phosphorylation PhosphoSitePlus   UniProt 21183079
T716 O-Glycosylation GlyGen 31616917, 32782141
T716 Phosphorylation PhosphoSitePlus
T717 O-Glycosylation GlyGen   PhosphoSitePlus 28528544, 32848054, 32782141, ...36852467, 18519567, 26866564, 25153642, 28135057, 28280036, 22517741, 22645316, 24788674, 35822049, 37058110
S719 O-Glycosylation GlyGen 31616917, 28528544, 32848054, ...32782141, 36852467, 18519567, 26866564, 25153642, 28135057, 28280036, 22517741, 22645316, 24788674, 35822049, 37058110
T721 O-Glycosylation GlyGen 32782141
T721 Phosphorylation PhosphoSitePlus
S727 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 26919063, 36030776, 15705584, ...30993885, 17683579, 22614008, 14617800, 24850910, 16418226, 29382715, 29047406, 31770366, 28542400, 23750710, 28338101, 28625915, 26198700, 15465816, 21617181, 35452800, 30996264, 32308756, 24655440, 15096606, 22875246, 29683527, 17283176, 11278353, 12049654, 10896772, 19696070, 17583567, 23216800, 11553624, 25788267, 27050391, 32694788, 28849098, 26980746, 31073117, 26034351, 26512963, 20151299, 23329648, 35312906, 29074644, 31862381, 16172266, 28320842, 27306323, 29340087, 24975845, 35806005, 35732128, 17606840, 14673173, 29263930, 25741592, 25568075, 21291541, 32732870, 28445952, 25460165, 26061710, 32041943, 28106119, 27384491, 23693126, 31683879, 27579617, 30924297, 28383063, 19380824, 24819473, 27537526, 21223971, 25880134, 21997191, 29867489, 21183079, 24152426, 26241748, 29729074, 26764350, 22110749, 32797246, 26848037, 24019511, 33361763, 23374901, 25150294, 24302476, 20871632, 26573296, 27102301, 15781265, 18723372, 29202102, 23807298, 23364341, 23665018, 7543024, 15004007, 33595435, 33859760, 17064687, 24410832, 21480396, 30206377, 18403479, 29507229, 20595392, 28082079, 35585990, 32820305, 22454509, 24260381, 27449092, 25412315, 22268811, 22911886, 27641629, 28669599, 27835873, 31780948, 26255791
S727 Phosphorylation P16054 (Prkce) PhosphoSitePlus 17283176
S727 Phosphorylation P28867 (Prkcd) PhosphoSitePlus 16418226
S727 Phosphorylation P47811 (Mapk14) PhosphoSitePlus 14617800
S727 Phosphorylation P49615 (Cdk5) PhosphoSitePlus 15096606
S727 Phosphorylation P53349 (Map3k1) PhosphoSitePlus 11278353
S727 Phosphorylation Q62406 (Irak1) PhosphoSitePlus 15465816
S727 Phosphorylation Q8C050 (Rps6ka5) PhosphoSitePlus 11553624
S727 Phosphorylation Q91Y86 (Mapk8) PhosphoSitePlus 11553624
S727 Phosphorylation Q9JLN9 (Mtor) PhosphoSitePlus 26573296
S727 Phosphorylation Q9QZR5 (Hipk2) RLIMS-P+ 17064687
S754 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y705 Phosphorylation PRO 26026268
S727 Phosphorylation PRO 15096606, 14617800
Site PTM Type PTM Enzyme Score Source PMID
Y705 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y704 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000037009 (mSTAT3/iso:Stat3A/Phos:1) pY705 PRO 26026268
PR:000045779 (mSTAT3/iso:Stat3A/Phos:2) pS727 PRO 14617800, 15096606


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P40189 (IL6ST) Y905 P42227 (Stat3) unknown eFIP 33491667
Phosphorylation P42227 (Stat3) Y705 P51642 (Cntf) unknown eFIP 23109669
Phosphorylation P42227 (Stat3) Y705 P54227 (Stmn1) increased_association eFIP 27021905
Phosphorylation P42227 (Stat3) Y705 Q00560 (Il6st) inhibited_association eFIP 32527985
Phosphorylation P42227 (Stat3) Y705 inhibited_association eFIP 32527985
Phosphorylation P42227 (Stat3) Y705 Q01279 (Egfr) unknown eFIP 31217524


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q91WG4-1 (mELP2/iso:1) Interaction PR:P42227 (mSTAT3) PRO 10954736