Protein Information

Cytoscape View


UniProt AC / UniProt ID P42224 / STAT1_HUMAN
Protein Name Signal transducer and activator of transcription 1-alpha/beta
Gene Name Name: STAT1
Organism Homo sapiens (Human)

PRO ID PR:P42224
DAG View
PRO Name signal transducer and activator of transcription 1-alpha/beta (human)
Definition A signal transducer and activator of transcription 1 that is encoded in the genome of human.
Short Label hSTAT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42224 (STAT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S2 Phosphorylation PhosphoSitePlus
R31 Methylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K114 Methylation UniProt 28753426
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K175 Methylation UniProt 28753426
K175 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
K193 Sumoylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K296 Methylation UniProt 28753426
K296 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K366 Methylation UniProt 28753426
K366 Ubiquitination PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K410 Acetylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K413 Acetylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K525 Methylation UniProt 28753426
K525 Ubiquitination PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K637 Methylation UniProt 28753426
K637 Ubiquitination PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
K652 Sumoylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K665 Methylation UniProt 28753426
K665 Ubiquitination PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K679 Sumoylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
T699 Phosphorylation PhosphoSitePlus
Y701 Phosphorylation P52333 (JAK3) , P22455 (FGFR4) , P22607 (FGFR3) , P00533 (EGFR) , O60674 (JAK2) , P12931 (SRC) , P23458 (JAK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21545749, 17383622, 23845085, ...21351482, 16729885, 7504784, 26232434, 29033931, 28680969, 31202985, 19551150, 10748192, 21677781, 10820245, 17525742, 28430601, 7657660, 28753426, 10453004, 21654841, 23174178, 26783516, 31408005, 25690042, 22038826, 24065129, 23178573, 19088846, 16314732, 15297606, 18574148, 23257612, 19349465, 17696225, 28422713, 26113305, 25271420, 17986321, 27796300, 19052084, 24725474, 30007645, 21968657, 26859759, 20738848, 12799548, 23013371, 22527947, 23086340, 23637938, 24014650, 31205408, 23917221, 12232802, 17579625, 26479788, 19396596, 19397895, 12068083, 27791205, 20504369, 21992896, 27080594, 21533215, 17325127, 11675348, 16934001, 25340519, 12971583, 29474442, 23440042, 17622177, 19404407, 24131713, 17561467, 29071017, 28059079, 23349666, 11777927, 20353823, 31085626, 16059651, 18941537, 16324217, 15994321, 17488182, 19367337, 29751820, 26735690, 24886089, 21999474, 22126015, 29470957, 16418217, 25921060, 25535969, 15284024, 15322115, 24728078, 11886239, 27074819, 29374380, 7690989, 15140960, 21135090, 30842274, 25858560, 18956976, 11309387, 30373602, 26265185, 27994058, 12804067, 27862183, 16918696, 17897103, 21189227, 24449862, 28432285, 9353323, 30886199, 17072862, 21311224, 26155422, 25605239, 19915063, 16464493, 11438544, 19846878, 21345084, 28425456, 25686822, 24911872, 9724754, 20006573, 17785551, 12526087, 12883649, 25062500, 11023524, 11972023, 20974954, 10918587, 23043228, 24319264, 23825585, 23245396, 27378243, 14978237, 8523587, 29930380, 30940163, 23221969, 24839978, 30150992, 17237409, 22306001, 29371942, 25170834, 24646078, 15182726, 19502801, 25950470, 28676732, 27387064, 26901336, 10383940, 24788809, 24838635, 9649436, 30455980, 19174562, 29604049, 27457515, 29796172, 20035788, 29239838, 23580655, 28550731, 15320963, 17075845, 22435755, 10542198, 29855346, 28471454, 22996189, 22065572, 7592750, 11641425, 29234062, 26604104, 29859868, 27434509, 11823427, 8940092, 17277783, 22355301, 24699362, 12637327, 26141950, 22920439, 26839680, 26351076, 21303487, 29270166, 27486982, 23633948, 18817573, 29946223
K703 Sumoylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
T704 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22065572, 27434509
S710 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
S727 Phosphorylation Q13554 (CAMK2B) , P45984 (MAPK9) , P49336 (CDK8) , Q05655 (PRKCD) , P68400 (CSNK2A1) , Q14164 (IKBKE) , Q15759 (MAPK11) , P19525 (EIF2AK2) , O75582 (RPS6KA5) , P27361 (MAPK3) , P28482 (MAPK1) , P45983 (MAPK8) , Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 12807916, 17383622, 21351482, ...25995822, 28680969, 19551150, 10748192, 10820245, 25535969, 27862183, 26783516, 31408005, 12817007, 19690332, 21783819, 18574148, 16918696, 19349465, 17933493, 15728510, 29434310, 24838635, 26113305, 12799548, 12671680, 23013371, 15850832, 28262979, 24725474, 10753717, 26479788, 15585657, 12068083, 10940874, 18190974, 15695932, 21992896, 21533215, 23637938, 15182726, 11675348, 12971583, 29859868, 15994429, 14648593, 17293456, 30007645, 12856330, 29071017, 16799645, 22823229, 23349666, 20504369, 20353823, 25340519, 16059651, 18941537, 15994321, 16324217, 16343349, 14963018, 29751820, 26735690, 9353323, 21999474, 10523304, 29470957, 15322115, 12232043, 23352233, 16516295, 27074819, 12637327, 30842274, 20068231, 19396596, 27994058, 28086195, 21084836, 11884587, 17897103, 21189227, 24449862, 12232802, 17565448, 30886199, 27791205, 10918594, 23186163, 19214187, 10878008, 17371985, 19915063, 11438544, 19846878, 16260419, 28431406, 22110204, 27378243, 25686822, 24911872, 29374380, 18378670, 19740326, 12526087, 7543024, 12883649, 27434509, 11972023, 17258468, 12748293, 23825585, 9399961, 8523587, 22126015, 19801665, 18669648, 17502367, 19502801, 25950470, 27387064, 11309387, 10645003, 10383940, 28234991, 12811837, 24788809, 28560754, 9649436, 29796172, 20035788, 23760261, 26719274, 22920439, 28422713, 29239838, 18691976, 28550731, 25226283, 25941617, 17075845, 22435755, 23449448, 10542198, 24069555, 29855346, 28471454, 26353965, 22996189, 16204068, 21303487, 22065572, 16257975, 11777927, 28542650, 20675591, 25753288, 21878628, 24699362, 21135090, 26141950, 23597922, 11839738, 17785783, 10570180, 18817573
S740 Phosphorylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
T749 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K410 Acetylation PR:Q92793 (hCREBBP) PRO 16481475
K413 Acetylation PR:Q92793 (hCREBBP) PRO 16481475
Y701 Phosphorylation P23458 (JAK1) , P06239 (LCK) , P29597 (TYK2) , O60674 (JAK2) , P10721 (KIT) , P22607 (FGFR3) , P00533 (EGFR) , P22455 (FGFR4) HPRD   PRO 9355737, 10918587, 7657660, ...15322115, 7543024, 10982844, 11839738, 12817007, 11152457, 7690989, 11294897, 12637327
K703 Sumoylation PR:000015829 (SUMO1) PRO 12855578
S727 Phosphorylation O75582 (RPS6KA5) , Q13555 (CAMK2G) , Q05655 (PRKCD) , PR:Q05655 (hPRKCD) HPRD   PRO 18691976, 15322115, 20058876, ...7543024, 18452278, 11839738, 11972023, 18669648, 14963018, 7690989, 9355737, 12637327, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y701 Phosphorylation P06239 (LCK) , O60674 (JAK2) , P22607 (FGFR3) , P23458 (JAK1) , P00533 (EGFR) , P22455 (FGFR4) , P29597 (TYK2) HPRD 10918587, 7657660, 15322115, ...7543024, 11839738, 12817007, 7690989, 12637327


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049364 (hSTAT1/Phos:1) pY701 PRO
PR:000026858 (hSTAT1/iso:1/Phos:1) pY701 PRO 7657660
PR:000027889 (hSTAT1/iso:1/Phos:3) pS727 PR:Q05655 (hPRKCD) PRO 15322115
PR:000027891 (hSTAT1/iso:1/Sumo:1) suK703 PR:000015829 (SUMO1) PRO 12855578
PR:000028637 (hSTAT1/iso:1/Ac:1) acK410,acK413 PR:Q92793 (hCREBBP) PRO 16481475


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42224 (STAT1) S727 P52630 (STAT2) unknown eFIP 18574148
Phosphorylation P42224 (STAT1) S727 Q9NZJ5 (EIF2AK3) increased_association eFIP 28471454
Phosphorylation P42224 (STAT1) S727 O75925 (PIAS1) increased_association eFIP 17897103
Phosphorylation Q9Y4C1 (KDM3A) S264 P42224 (STAT1) unknown eFIP 25535969


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K114 E114 Biomuta DOID:1324 / lung cancer [ tcga ]
S162 I162 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T184 I184 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K201 M201 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K298 Q298 Biomuta DOID:1909 / melanoma [ cosmic ]
K350 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K366 N366 Biomuta DOID:1324 / lung cancer [ cosmic ]
K511 E511 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S583 G583 Biomuta DOID:363 / uterine cancer [ tcga ]
K703 E703 Biomuta DOID:363 / uterine cancer [ tcga ]
T704 N704 Biomuta DOID:9256 / colorectal cancer [ tcga ]