iPTMnet Report for P42166 (TMPO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42166 / LAP2A_HUMAN
Protein Name Lamina-associated polypeptide 2, isoform alpha
Gene Name Name: TMPO
Synonyms:LAP2;
Organism Homo sapiens (Human)

Interactive Sequence View

Select/align proteoforms across species


P42166 (TMPO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N23 N-Glycosylation GlyGen 24190977
N24 N-Glycosylation GlyGen 24190977
T57 Phosphorylation UniProt 18669648
S59 Phosphorylation UniProt 21406692
S66 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 19690332
S67 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 19690332
T74 Phosphorylation UniProt 18691976, 21406692, 23186163, ...18220336, 18669648, 24275569, 19690332, 20068231
S79 Phosphorylation UniProt 18669648, 23186163, 19690332
T154 Phosphorylation phospho.ELM   UniProt 17081983, 19690332
S156 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S159 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
T164 Phosphorylation UniProt 18669648, 23186163
S167 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 32574038, 29351928, 34019948, 35083852, 32119511, 35289036, 35254053, 22121020, 22661428
S168 Phosphorylation phospho.ELM   UniProt 15302935, 23186163
S180 Phosphorylation PhosphoSitePlus
R182 Methylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
S184 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T211 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
R264 Methylation PhosphoSitePlus
K269 Sumoylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus   UniProt 23186163
S279 Phosphorylation PhosphoSitePlus
K281 Methylation PhosphoSitePlus
K281 Sumoylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S291 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 32574038, 29351928, 34019948, 35083852, 32119511, 35289036, 35254053, 22121020, 22661428
S292 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 32574038, 29351928, 34019948, 35083852, 32119511, 35289036, 35254053, 22121020, 22661428
S295 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 32574038, 29351928, 34019948, 35083852, 32119511, 35289036, 35254053, 22121020, 22661428
S296 Phosphorylation PhosphoSitePlus
S306 O-Glycosylation GlyGen 34846842, 32574038
S306 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus   UniProt 24275569
K315 Ubiquitination PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
C341 S-Nitrosylation dbSNO 26338901
S348 Phosphorylation PhosphoSitePlus
S351 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18669648, 24275569, 19690332, 20068231, 17924679
S354 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S355 Phosphorylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K356 Sumoylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K410 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 18220336, ...18234856, 18669648, 19690332, 20068231, 17924679
S424 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
K428 Ubiquitination PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
K435 Acetylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
R511 Methylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
C629 S-Nitrosylation dbSNO 26338901
T642 Phosphorylation PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
K656 Acetylation PhosphoSitePlus   UniProt 19608861
K656 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
K667 Sumoylation PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
K674 Methylation PhosphoSitePlus
K674 Sumoylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 20068231
T12 Phosphorylation HPRD 20068231
T57 Phosphorylation HPRD 18669648
S59 Phosphorylation HPRD 19651622, 20068231
S66 Phosphorylation HPRD 19413330, 18691976, 17287340, ...20230923, 20058876, 19664994, 19651622, 18452278, 17322306, 18669648, 18707149, 20166139, 19415658, 20068231
S67 Phosphorylation HPRD 19413330, 18691976, 17287340, ...20230923, 15302935, 19664994, 18452278, 19651622, 18669648, 20058876, 18707149, 20166139, 19415658, 20068231
T74 Phosphorylation HPRD 19413330, 18691976, 20230923, ...20058876, 19664994, 18452278, 17322306, 18669648, 19651622, 20166139, 19415658, 20068231
S79 Phosphorylation HPRD 18669648, 17287340, 17081983
S87 Phosphorylation HPRD 17287340
T96 Phosphorylation HPRD 17287340
T99 Phosphorylation HPRD 17287340
T137 Phosphorylation HPRD 17287340, 20068231
T154 Phosphorylation HPRD 18669648, 17081983, 20068231
S156 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18212344
S158 Phosphorylation HPRD 18691976, 18491316, 19664995, ...18452278, 17322306, 18669648, 20166139, 20068231
S159 Phosphorylation HPRD 19413330, 18491316, 17287340, ...17081983, 19664995, 18452278, 18669648, 20068231
T160 Phosphorylation HPRD 19413330, 18491316, 17287340, ...18767875, 20058876, 19691289, 19664995, 17322306, 18669648, 18452278, 19415658, 20068231, 17924679
T164 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S166 Phosphorylation HPRD 20166139, 18669648, 20068231
S167 Phosphorylation HPRD 18669648
S168 Phosphorylation HPRD 19651622, 18669648, 15302935, ...19691289
T172 Phosphorylation HPRD 18669648
S177 Phosphorylation HPRD 19651622, 20068231
S184 Phosphorylation HPRD 19651622, 17081983, 20068231
S272 Phosphorylation HPRD 17287340
S294 Phosphorylation HPRD 20068231
S295 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD 18669648, 17287340, 20068231
S351 Phosphorylation HPRD 19664995, 18691976, 19691289, ...18452278, 19651622, 17322306, 18669648, 17924679, 19415658, 20068231, 20068230
S354 Phosphorylation HPRD 18669648, 20068231
S355 Phosphorylation HPRD 20068231
S370 Phosphorylation HPRD 18669648, 20068231
S424 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 18452278, 18669648, 19415658, 20068231, 17924679
S436 Phosphorylation HPRD 18669648, 20068231
S442 Phosphorylation HPRD 18669648, 20068231, 18452278
S444 Phosphorylation HPRD 18669648, 20068231, 18452278
S458 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 18452278
S670 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 N59 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T96 K96 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T99 P99 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T99 N99 Biomuta DOID:1324 / lung cancer [ cosmic ]
S158 Y158 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S180 F180 Biomuta DOID:363 / uterine cancer [ icgc ]
R182 I182 Biomuta DOID:363 / uterine cancer [ icgc ]
T212 A212 Biomuta DOID:1324 / lung cancer [ cosmic ]
S291 N291 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S292 Y292 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S295 Y295 Biomuta DOID:363 / uterine cancer [ icgc ]
K323 E323 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K323 Q323 Biomuta DOID:363 / uterine cancer [ icgc ]
K334 I334 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S335 R335 Biomuta DOID:3571 / liver cancer [ cosmic ]
S351 L351 Biomuta DOID:363 / uterine cancer [ icgc ]
S365 I365 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S370 Y370 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K410 T410 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K435 N435 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K519 R519 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K659 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K685 T685 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]