iPTMnet Report for P41440 (SLC19A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P41440 / S19A1_HUMAN
Protein Name Reduced folate transporter
Gene Name Name: SLC19A1
Synonyms:FLOT1,RFC1;
Organism Homo sapiens (Human)

PRO ID PR:P41440
DAG View
PRO Name reduced folate transporter (human)
Definition A reduced folate transporter that is encoded in the genome of human.
Short Label hSLC19A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41440 (SLC19A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S4 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
K10 Ubiquitination PhosphoSitePlus
C30 Methylation IEDB 31844290
Y35 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
N58 N-Glycosylation GlyGen   UniProt 9767079
T222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus   UniProt 23186163
K237 Ubiquitination PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus   UniProt 20068231
S503 Phosphorylation PhosphoSitePlus   UniProt 20068231
S507 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
Y524 Phosphorylation PhosphoSitePlus
S583 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 20068231
S5 Phosphorylation HPRD 20068231
S225 Phosphorylation HPRD 19664994
S499 Phosphorylation HPRD 20068231
S503 Phosphorylation HPRD 20068231
S583 Phosphorylation HPRD 19413330, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K237 E237 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y305 F305 Biomuta DOID:4159 / skin cancer [ cosmic ]