Protein Information

Cytoscape View


UniProt AC / UniProt ID P41279 / M3K8_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 8
Gene Name Name: MAP3K8
Synonyms:COT,ESTF;
Organism Homo sapiens (Human)

PRO ID PR:P41279
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 8 (human)
Definition A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human.
Short Label hMAP3K8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41279 (MAP3K8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus   RLIMS-P 16806191, 19754427
T80 Phosphorylation UniProt 17472361
S125 Phosphorylation PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
S141 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
Y153 Phosphorylation PhosphoSitePlus
T290 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 16806191, 15699325, 15466476, ...19754427, 26456302
S334 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S400 Phosphorylation Q9P1W9 (PIM2) , P31749 (AKT1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12138205, 23557442, 19754427, ...15548703, 17709378, 24912162, 22988300, 17472361, 26456302
S413 Phosphorylation Q9P1W9 (PIM2) , P31749 (AKT1) neXtProt   phospho.ELM   Signor 12138205, 15548703
S443 Phosphorylation P41279 (MAP3K8) PhosphoSitePlus   RLIMS-P+   UniProt 17472361, 24912162
Site PTM Type PTM Enzyme Score Source PMID
S141 Phosphorylation HPRD 19651622, 19664994, 18669648, ...20058876
S400 Phosphorylation P31749 (AKT1) HPRD 12138205
S413 Phosphorylation P31749 (AKT1) HPRD 12138205


P41279 (MAP3K8) as PTM Enzyme



Substrate Site Score Source PMID
O14757 (CHEK1) S345 PhosphoSitePlus 19804365
P00519 (ABL1) T735 PhosphoSitePlus 19804365
P06493 (CDK1) T161 PhosphoSitePlus 19804365
P06748 (NPM1) T199 PhosphoSitePlus 24998852
P15311 (EZR) T567 PhosphoSitePlus 19804365
P16220 (CREB1) S133 PhosphoSitePlus 19804365
P26038 (MSN) T558 PhosphoSitePlus 19804365
P35241 (RDX) T564 PhosphoSitePlus 19804365
P36507 (MAP2K2) S222 phospho.ELM   PhosphoSitePlus   Signor 15466476, 19804365
P36507 (MAP2K2) S226 phospho.ELM   PhosphoSitePlus   Signor 15466476, 19804365
P41279 (MAP3K8) S443 RLIMS-P+ 24912162
P46734 (MAP2K3) S218 PhosphoSitePlus 19804365
P52564 (MAP2K6) S207 PhosphoSitePlus 19804365
P53350 (PLK1) S137 PhosphoSitePlus 19804365
P53350 (PLK1) T210 PhosphoSitePlus   Signor 12207013, 19804365
Q02750 (MAP2K1) S218 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8631303, 15466476, 19804365
Q02750 (MAP2K1) S222 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8131746, 15466476, 19804365, ...8631303
Q02750 (MAP2K1) S244 Signor 8131746
Q02750 (MAP2K1) S248 Signor 8131746
Q04637 (EIF4G1) S1147 PhosphoSitePlus 19804365
Q13526 (PIN1) S16 RLIMS-P+ 24265246
Q13541 (EIF4EBP1) T70 PhosphoSitePlus 19804365
Q15418 (RPS6KA1) S380 PhosphoSitePlus 19804365
Q99558 (MAP3K14) T559 HPRD   Signor 11278268, 9742107


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048311 (hMAP3K8/Phos:2) pT290,pS400 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000028994 (hAKT1/iso:1/Phos:1) Interaction PR:P41279-1 (hMAP3K8/iso:1) PRO 12138205


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S125 F125 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]