Protein Information

Cytoscape View


UniProt AC / UniProt ID P41250 / GARS_HUMAN
Protein Name Glycine--tRNA ligase
Gene Name Name: GARS
Organism Homo sapiens (Human)

PRO ID PR:P41250
DAG View
PRO Name glycine--tRNA ligase (human)
Definition A glycine--tRNA ligase that is encoded in the genome of human.
Short Label hGARS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41250 (GARS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 23186163
S37 Phosphorylation PhosphoSitePlus
S53 Phosphorylation HPRD   PhosphoSitePlus 20068231
S54 Phosphorylation HPRD   PhosphoSitePlus 20068231
K80 Ubiquitination PhosphoSitePlus
K82 Sumoylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K204 Acetylation PhosphoSitePlus   UniProt 19608861
K204 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
C466 S-Nitrosylation dbSNO 19483679
Y467 Phosphorylation PhosphoSitePlus
C471 S-Nitrosylation dbSNO 19483679
K484 Acetylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
K501 Acetylation PhosphoSitePlus   UniProt 19608861
K501 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
T548 Phosphorylation HPRD   PhosphoSitePlus 20068231
T552 Phosphorylation HPRD   PhosphoSitePlus 20068231
K553 Ubiquitination PhosphoSitePlus
K559 Acetylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
R596 Methylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
R687 Methylation PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
T736 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 R37 Biomuta DOID:1909 / melanoma [ cosmic ]
Y148 H148 Biomuta DOID:363 / uterine cancer [ tcga ]
K224 Q224 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y414 C414 Biomuta DOID:363 / uterine cancer [ tcga ]
R596 * Biomuta DOID:363 / uterine cancer [ tcga ]
R687 S687 Biomuta DOID:3571 / liver cancer [ icgc ]