Protein Information

Cytoscape View

UniProt AC / UniProt ID P41240 / CSK_HUMAN
Protein Name Tyrosine-protein kinase CSK
Gene Name Name: CSK
Organism Homo sapiens (Human)

PRO ID PR:P41240
DAG View
PRO Name tyrosine-protein kinase CSK (human)
Definition A tyrosine-protein kinase CSK that is encoded in the genome of human.
Short Label hCSK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P41240 (CSK) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
Y18 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17192257, 9148770
S186 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus   RLIMS-P 31011187
Y304 Phosphorylation P41240 (CSK) HPRD   neXtProt   RLIMS-P   UniProt 9148770
K329 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S364 Phosphorylation P17612 (PRKACA) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28522807, 11181701, 20826718, ...27457684, 28098256, 12600271, 31125786, 23378895
K393 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation P41240 (CSK) PhosphoSitePlus   RLIMS-P   UniProt 1945408, 21145940, 23923048, ...7683131
K420 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus

P41240 (CSK) as PTM Enzyme

Substrate Site Score Source PMID
O15492 (RGS16) Y168 HPRD 12588871, 11602604
P05412 (JUN) Y26 RLIMS-P+ 16740711
P05412 (JUN) Y170 RLIMS-P+ 16740711, 19818398
P06239 (LCK) Y505 HPRD   PhosphoSitePlus   Signor 19901323, 18691976, 12485116, ...1639064, 15144186, 17897955, 16497976
P06241-3 (FYN) Y476 HPRD 18691976, 1985196
P06241-2 (FYN) Y528 HPRD 18691976, 1985196
P06241 (FYN) Y531 HPRD   phospho.ELM 18691976, 1985196
P06396-2 (GSN) Y35 HPRD 10210201
P06396-2 (GSN) Y358 HPRD 10210201
P06396-2 (GSN) Y414 HPRD 10210201
P06396-2 (GSN) Y552 HPRD 10210201
P06396-2 (GSN) Y600 HPRD 10210201
P07947 (YES1) Y537 PhosphoSitePlus 16439366
P07948 (LYN) Y508 HPRD   neXtProt   phospho.ELM   Signor 19901323, 18691976, 8612628, ...15626731, 7935444, 18452278, 19651622, 18669648, 9171348, 1722201, 20068231, 16497976
P08575 (PTPRC) Y1218 Signor 7507203
P08631-1 (HCK) Y522 HPRD 11976726
P09769 (FGR) Y523 HPRD   neXtProt   phospho.ELM 8612628, 7515063
P12931 (SRC) Y530 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17855352, 18614016, 9208935, ...7678701, 12387813, 16790421, 12606547, 12468645, 11007774
P16284 (PECAM1) Y713 neXtProt 9624175
P41240 (CSK) Y304 HPRD   neXtProt 9148770
P41240 (CSK) Y416 UniProt 1945408
P42685 (FRK) Y497 neXtProt 7696183
P49023-2 (PXN) Y40 HPRD 11695992
P49023-2 (PXN) Y88 HPRD 11695992, 17389395, 18707149
Q8TD08-1 (MAPK15) T175 HPRD 11875070
Q8TD08-1 (MAPK15) Y177 HPRD 11875070

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y998 P41240 (CSK) unknown eFIP 16729043
Phosphorylation P04626 (ERBB2) Y1248 P41240 (CSK) unknown eFIP 9461599
Phosphorylation P06241 (FYN) Y420 P41240 (CSK) unknown eFIP 7524477
Phosphorylation P08069 (IGF1R) Y973 P41240 (CSK) unknown eFIP 10026153
Phosphorylation P08575 (PTPRC) Y1218 P41240 (CSK) unknown eFIP 7507203
Phosphorylation P21860 (ERBB3) Y1199 P41240 (CSK) unknown eFIP 16729043
Phosphorylation Q03135 (CAV1) Y14 P41240 (CSK) unknown eFIP 24632723
Phosphorylation Q03135 (CAV1) Y14 P41240 (CSK) unknown eFIP 16678999
Phosphorylation Q08345 (DDR1) Y586 P41240 (CSK) unknown eFIP 22057045
Phosphorylation Q6GTX8 (LAIR1) Y281 P41240 (CSK) unknown eFIP 16380958
Phosphorylation Q8NHL6 (LILRB1) Y562 P41240 (CSK) unknown eFIP 15474475
Phosphorylation Q9NWQ8 (PAG1) Y317 P41240 (CSK) unknown eFIP 10790433
Phosphorylation Q9QZK7 (Dok3) Y325 P41240 (CSK) unknown eFIP 14993273
Phosphorylation Q9Y2R2 (PTPN22) S751 P41240 (CSK) increased_association eFIP 32184287

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 Y10 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S10 F10 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K86 N86 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
K329 R329 Biomuta DOID:363 / uterine cancer [ tcga ]