Protein Information

Cytoscape View


UniProt AC / UniProt ID P41240 / CSK_HUMAN
Protein Name Tyrosine-protein kinase CSK
Gene Name Name: CSK
Organism Homo sapiens (Human)

PRO ID PR:P41240
DAG View
PRO Name tyrosine-protein kinase CSK (human)
Definition A tyrosine-protein kinase CSK that is encoded in the genome of human.
Short Label hCSK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41240 (CSK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17192257, 9148770
S186 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation P41240 (CSK) HPRD   neXtProt   RLIMS-P   UniProt 9148770
K329 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
S364 Phosphorylation P17612 (PRKACA) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11181701, 20826718, 27457684, ...28098256, 12600271, 23378895
K393 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation P41240 (CSK) PhosphoSitePlus   RLIMS-P   UniProt 1945408, 21145940, 23923048, ...24103328


P41240 (CSK) as PTM Enzyme



Substrate Site Score Source PMID
O15492 (RGS16) Y168 HPRD 12588871, 11602604
O43353 (RIPK2) Y381 UniProt 21887730
O60331 (PIP5K1C) Y649 UniProt 15738269
P06239 (LCK) Y505 HPRD   PhosphoSitePlus   Signor   UniProt 19901323, 18691976, 12485116, ...1639064, 15144186, 17897955, 15592455, 16497976
P06241-3 (FYN) Y476 HPRD 18691976, 1985196
P06241-2 (FYN) Y528 HPRD 18691976, 1985196
P06241 (FYN) Y531 HPRD   phospho.ELM   UniProt 18691976, 1985196
P06396-2 (GSN) Y35 HPRD 10210201
P06396-2 (GSN) Y358 HPRD 10210201
P06396-2 (GSN) Y414 HPRD 10210201
P06396-2 (GSN) Y552 HPRD 10210201
P06396-2 (GSN) Y600 HPRD 10210201
P07947 (YES1) Y537 PhosphoSitePlus   UniProt 18691976, 16439366
P07948-1 (LYN) Y508 HPRD   neXtProt   phospho.ELM   Signor   UniProt 19901323, 18691976, 8612628, ...15626731, 7935444, 18452278, 19651622, 18669648, 9171348, 15592455, 1722201, 20068231, 16497976
P08575 (PTPRC) Y1216 phospho.ELM   PhosphoSitePlus   Signor 7507203
P08631-1 (HCK) Y522 HPRD 11976726
P09769 (FGR) Y523 HPRD   neXtProt   phospho.ELM 8612628, 7515063
P10275 (AR) Y225 UniProt 17045208
P10275 (AR) Y269 UniProt 17045208
P10275 (AR) Y309 UniProt 17045208
P10275 (AR) Y348 UniProt 17045208
P10275 (AR) Y359 UniProt 17045208
P10275 (AR) Y364 UniProt 17045208
P10275 (AR) Y365 UniProt 17045208
P10275 (AR) Y395 UniProt 17045208
P10275 (AR) Y535 UniProt 17045208
P10275 (AR) Y552 UniProt 17045208
P10275 (AR) Y916 UniProt 17045208
P12931 (SRC) Y530 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17855352, 19369195, 18614016, ...9208935, 7678701, 12387813, 16790421, 12606547, 12468645, 11007774
P13639 (EEF2) Y265 UniProt 24648518
P13639 (EEF2) Y373 UniProt 24648518
P15941 (MUC1) Y1229 UniProt 11152665
P16284 (PECAM1) Y713 neXtProt 9624175
P35222 (CTNNB1) Y86 UniProt 11279024
P35222 (CTNNB1) Y654 UniProt 11279024
P41240 (CSK) Y304 HPRD   neXtProt 9148770
P41240 (CSK) Y416 UniProt 1945408
P42685 (FRK) Y497 neXtProt 7696183
P49023-2 (PXN) Y40 HPRD 11695992
P49023-2 (PXN) Y88 HPRD 11695992, 17389395, 18707149
Q8TD08-1 (MAPK15) T175 HPRD 11875070
Q8TD08-1 (MAPK15) Y177 HPRD 11875070


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03135 (CAV1) Y14 P41240 (CSK) unknown eFIP 24632723
Phosphorylation Q9H400 (LIME1) Y167 P41240 (CSK) unknown eFIP 14610046