Protein Information

Cytoscape View


UniProt AC / UniProt ID P41236 / IPP2_HUMAN
Protein Name Protein phosphatase inhibitor 2
Gene Name Name: PPP1R2
Synonyms:IPP2;
Organism Homo sapiens (Human)

PRO ID PR:P41236
DAG View
PRO Name protein phosphatase inhibitor 2 (human)
Definition A protein phosphatase inhibitor 2 that is encoded in the genome of human.
Short Label hPPP1R2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41236 (PPP1R2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 20068231
S7 Phosphorylation PhosphoSitePlus
T19 Phosphorylation HPRD 18669648, 20068231
S20 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
S23 Phosphorylation HPRD   PhosphoSitePlus 18669648
S24 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
S44 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   Signor   UniProt 18250156
T55 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
S72 Phosphorylation P27448 (MARK3) HPRD   PhosphoSitePlus 18669648, 25028520
T73 Phosphorylation P49841 (GSK3B) , Q00535 (CDK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 12697755, 15302935, 11320080, ...24195737, 26655089, 12761178
Y75 Phosphorylation HPRD   PhosphoSitePlus 18669648
S77 Phosphorylation HPRD 18669648
S87 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) , O94921 (CDK14) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18491316, 8288648, 15302935, ...18669648, 9405437, 24195737, 25028520, 19690332
T89 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
T92 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 18220336
K103 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
S121 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18491316, 18088087, 17081983, ...8288648, 15302935, 23506001, 19651622, 18669648, 20166139, 17287340, 9405437, 19415658, 20068231, 18212344
S122 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18491316, 17287340, 17081983, ...18767875, 8288648, 15302935, 23506001, 19651622, 20166139, 18088087, 9405437, 19415658, 20068231, 18212344
S127 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 23506001, 17081983
S130 Phosphorylation HPRD   PhosphoSitePlus 18510355, 19651622
K145 Acetylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T193 Phosphorylation HPRD   PhosphoSitePlus 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 L7 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R33 C33 Biomuta DOID:1612 / breast cancer [ cosmic ]
K103 T103 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S130 T130 Biomuta DOID:1909 / melanoma [ cosmic ]