Protein Information

Cytoscape View


UniProt AC / UniProt ID P41214 / EIF2D_HUMAN
Protein Name Eukaryotic translation initiation factor 2D
Gene Name Name: EIF2D
Synonyms:HCA56,LGTN;
Organism Homo sapiens (Human)

PRO ID PR:P41214
DAG View
PRO Name eukaryotic translation initiation factor 2D (human)
Definition A ligatin that is encoded in the genome of human.
Short Label hEIF2D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41214 (EIF2D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K4 Ubiquitination PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S184 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T219 Phosphorylation PhosphoSitePlus
S237 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S239 Phosphorylation phospho.ELM 18669648
K333 Acetylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus   UniProt 23186163
T366 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S184 Phosphorylation HPRD 15302935
S199 Phosphorylation HPRD 15302935
S237 Phosphorylation HPRD 18669648, 20068231
S239 Phosphorylation HPRD 18669648
S364 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S199 N199 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S361 Y361 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S364 F364 Biomuta DOID:1909 / melanoma [ icgc, tcga ]