iPTMnet Report for P41208 (CETN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P41208 / CETN2_HUMAN
Protein Name Centrin-2
Gene Name Name: CETN2
Synonyms:CALT,CEN2;
Organism Homo sapiens (Human)

PRO ID PR:P41208
DAG View
PRO Name centrin-2 (human)
Definition A centrin-2 that is encoded in the genome of human.
Short Label hCETN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41208 (CETN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Sumoylation PRO
A2 Acetylation UniProt 22814378
S3 Phosphorylation PhosphoSitePlus
K6 Acetylation PhosphoSitePlus
K6 Methylation PhosphoSitePlus
K7 Methylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
S20 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 17287340, ...17081983, 18767875, 18452278, 19651622, 18669648, 27869121, 23186163, 32387766, 20068231
K22 Ubiquitination PhosphoSitePlus
T26 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...19651622, 20068231
K30 Ubiquitination PhosphoSitePlus
T45 Phosphorylation RLIMS-P 26354417, 20980622
T47 Phosphorylation RLIMS-P 26354417, 20980622
K54 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus   RLIMS-P 26354417, 20980622
K120 Ubiquitination PhosphoSitePlus
S122 Phosphorylation neXtProt 21731694
S122 Phosphorylation O14965 (AURKA) neXtProt 21731694
K124 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus   RLIMS-P 24918055
S158 Phosphorylation PhosphoSitePlus   RLIMS-P 24918055
K167 Ubiquitination PhosphoSitePlus
S170 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11279195, 21731694
S170 Phosphorylation O14965 (AURKA) neXtProt   PhosphoSitePlus   Signor 21731694
S170 Phosphorylation P17612 (PRKACA) neXtProt 11279195
Y172 Phosphorylation RLIMS-P 24918055


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046692 (hCETN2/SumoLys+) su PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P41208 (CETN2) T138 A8K8P3 (SFI1) inhibited_association eFIP 24918055


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 Y14 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R16 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R16 Q16 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S20 N20 Biomuta DOID:184 / bone cancer [ cosmic ]
K65 N65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K108 R108 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K111 S111 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K120 T120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K120 N120 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S122 L122 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
K131 R131 Biomuta DOID:363 / uterine cancer [ icgc ]
K167 T167 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]