iPTMnet Report P41181 AQP2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P41181 / AQP2_HUMAN
Protein Name	Aquaporin-2
Gene Name	Name: AQP2
Organism	Homo sapiens (Human)

PRO ID	PR:P41181 DAG View
PRO Name	aquaporin-2 (human)
Definition	An aquaporin-2 that is encoded in the genome of human.
Short Label	hAQP2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P41181 (AQP2) as Substrate

P41181

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K228	Ubiquitination		score1	PhosphoSitePlus
	S256	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P UniProt	17138647, 29650969, 23559583, ...16120822, 17940053, 28630457, 12897058, 29799470, 28326667, 22778181, 32486031, 24829494, 19570884, 18678705, 16303856, 17116290, 18606813, 12194985, 18042467, 31888044, 19585583, 24876223, 18434387, 28710278, 27801846, 18695390, 32529500, 29145196, 10710543, 11076974, 20187088, 20971851
	S256	Phosphorylation	P17612 (PRKACA)	score2	PhosphoSitePlus	18042467
	S261	Phosphorylation		score4	PhosphoSitePlus RLIMS-P Signor	32164329, 28381458, 28931009, ...22778181, 29145196, 18434387, 28710278, 28108651, 20971851
	S261	Phosphorylation	Q07002 (CDK18)	score1	Signor	32164329
	S264	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	28710278, 22778181
	T269	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	32486031, 29145196, 22778181, ...28710278
	K270	Ubiquitination		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K228	E228	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ]
S264	I264	Biomuta		DOID:3571 / liver cancer [ cosmic ]