iPTMnet Report for P41091 (EIF2S3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P41091 / IF2G_HUMAN
Protein Name Eukaryotic translation initiation factor 2 subunit 3
Gene Name Name: EIF2S3
Synonyms:EIF2G;
Organism Homo sapiens (Human)

PRO ID PR:P41091
DAG View
PRO Name eukaryotic translation initiation factor 2 subunit 3 (human)
Definition A eukaryotic translation initiation factor 2 subunit 3, X-linked that is encoded in the genome of human.
Short Label hEIF2S3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41091 (EIF2S3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
T21 Phosphorylation HPRD 20068231
K27 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
K59 Methylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
T66 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 21854064
K70 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
C105 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
T109 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 26853435, 34019948, 29351928, 35132862, 32870666, 32119511
T109 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
C135 Methylation IEDB 31844290
K183 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
C236 Methylation IEDB 31844290
C236 S-Nitrosylation dbSNO 20140087, 22178444
Y238 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K312 Acetylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S320 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 26853435, 34019948, 29351928, 35132862, 32870666, 32119511
Y330 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
C348 Methylation IEDB 31844290
K400 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 L16 Biomuta DOID:4159 / skin cancer [ cosmic ]
K59 N59 Biomuta DOID:1319 / brain cancer [ cosmic, icgc, tcga ]
S104 F104 Biomuta DOID:363 / uterine cancer [ icgc ]
K125 R125 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K285 T285 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S302 F302 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T435 I435 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K466 N466 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]