iPTMnet Report for P41002 (CCNF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P41002 / CCNF_HUMAN
Protein Name Cyclin-F
Gene Name Name: CCNF
Synonyms:FBX1,FBXO1;
Organism Homo sapiens (Human)

PRO ID PR:P41002
DAG View
PRO Name cyclin-F (human)
Definition A cyclin-F that is encoded in the genome of human.
Short Label hCCNF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41002 (CCNF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
C218 Methylation IEDB 31844290
C240 Methylation IEDB 31844290
K264 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 29021214
S621 Phosphorylation P68400 (CSNK2A1) Signor 29021214
T680 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
S700 Phosphorylation RLIMS-P 30257202
S704 Phosphorylation RLIMS-P 30257202
S709 Phosphorylation PhosphoSitePlus   RLIMS-P 30257202
S713 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P41002 (CCNF) S704 Q9Y297 (BTRC) inhibited_association eFIP 30257202


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K495 N495 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K503 T503 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S709 I709 Biomuta DOID:184 / bone cancer [ cosmic ]
S713 F713 Biomuta DOID:2531 / hematologic cancer [ cosmic ]