iPTMnet Report for P40937 (RFC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40937 / RFC5_HUMAN
Protein Name Replication factor C subunit 5
Gene Name Name: RFC5
Organism Homo sapiens (Human)

PRO ID PR:P40937
DAG View
PRO Name replication factor C subunit 5 (human)
Definition A replication factor C subunit 5 that is encoded in the genome of human.
Short Label hRFC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40937 (RFC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K7 Sumoylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
R52 Methylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
R96 Methylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
C152 Methylation IEDB 31844290
S159 Phosphorylation PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
C238 S-Nitrosylation dbSNO 19483679
K270 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R52 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R52 Q52 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R96 Q96 Biomuta DOID:1319 / brain cancer [ cosmic ]
C152 S152 Biomuta DOID:263 / kidney cancer [ cosmic ]
S159 L159 Biomuta DOID:4159 / skin cancer [ cosmic ]
S159 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K194 R194 Biomuta DOID:3571 / liver cancer [ cosmic ]
S313 F313 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]