Protein Information

Cytoscape View


UniProt AC / UniProt ID P40925 / MDHC_HUMAN
Protein Name Malate dehydrogenase, cytoplasmic
Gene Name Name: MDH1
Synonyms:MDHA;
Organism Homo sapiens (Human)

PRO ID PR:P40925
DAG View
PRO Name malate dehydrogenase, cytoplasmic (human)
Definition A malate dehydrogenase, cytoplasmic that is encoded in the genome of human.
Short Label hMDH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40925 (MDH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 25944712
Y22 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K107 Acetylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K110 Methylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 22693256, 19608861
K118 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
K121 Acetylation UniProt 22693256
K125 Ubiquitination PhosphoSitePlus
C137 S-Nitrosylation dbSNO 26338901
K142 Acetylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
C154 S-Nitrosylation dbSNO 24105792
K164 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
R230 Methylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus   UniProt 24275569
S242 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
K298 Acetylation PhosphoSitePlus   UniProt 22693256, 19608861
K298 Ubiquitination PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus   UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
S241 Phosphorylation HPRD 19413330, 20166139, 20068231
S242 Phosphorylation HPRD 20068231
S333 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 F89 Biomuta DOID:1909 / melanoma [ tcga ]
K110 N110 Biomuta DOID:363 / uterine cancer [ tcga ]
S111 F111 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
K121 N121 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K149 N149 Biomuta DOID:363 / uterine cancer [ tcga ]
K164 E164 Biomuta DOID:1324 / lung cancer [ cosmic ]
K170 T170 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S188 F188 Biomuta DOID:1909 / melanoma [ tcga ]
S188 Y188 Biomuta DOID:363 / uterine cancer [ tcga ]
K199 R199 Biomuta DOID:363 / uterine cancer [ tcga ]
R230 H230 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K236 N236 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S245 Y245 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K298 N298 Biomuta DOID:263 / kidney cancer [ cosmic ]
S309 L309 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K312 N312 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]