iPTMnet Report for P40925 (MDH1)
Protein Information
UniProt AC / UniProt ID | P40925 / MDHC_HUMAN |
Protein Name | Malate dehydrogenase, cytoplasmic |
Gene Name | Name: MDH1 Synonyms:MDHA; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P40925 |
PRO Name | malate dehydrogenase, cytoplasmic (human) |
Definition | A malate dehydrogenase, cytoplasmic that is encoded in the genome of human. |
Short Label | hMDH1 |
Category | organism-gene |
P40925 (MDH1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 25944712 | ||
Y22 | Phosphorylation | score1 | PhosphoSitePlus | |||
T71 | Phosphorylation | score1 | PhosphoSitePlus | |||
K73 | Acetylation | score1 | PhosphoSitePlus | |||
K73 | Ubiquitination | score1 | PhosphoSitePlus | |||
S89 | Phosphorylation | score1 | PhosphoSitePlus | |||
K103 | Acetylation | score1 | PhosphoSitePlus | |||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
K107 | Acetylation | score1 | PhosphoSitePlus | |||
K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
K110 | Methylation | score1 | PhosphoSitePlus | |||
K110 | Ubiquitination | score1 | PhosphoSitePlus | |||
S111 | Phosphorylation | score1 | PhosphoSitePlus | |||
K118 | Acetylation | score4 | PhosphoSitePlus UniProt | 22693256, 19608861 | ||
K118 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y119 | Phosphorylation | score1 | PhosphoSitePlus | |||
K121 | Acetylation | score2 | UniProt | 22693256 | ||
K125 | Ubiquitination | score1 | PhosphoSitePlus | |||
C137 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K142 | Acetylation | score1 | PhosphoSitePlus | |||
K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
C154 | S-Nitrosylation | score0 | dbSNO | 24105792 | ||
K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
K170 | Ubiquitination | score1 | PhosphoSitePlus | |||
T174 | Phosphorylation | score1 | PhosphoSitePlus | |||
K179 | Ubiquitination | score1 | PhosphoSitePlus | |||
S188 | Phosphorylation | score1 | PhosphoSitePlus | |||
S189 | Phosphorylation | score1 | PhosphoSitePlus | |||
T190 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y192 | Phosphorylation | score1 | PhosphoSitePlus | |||
K199 | Ubiquitination | score1 | PhosphoSitePlus | |||
K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y210 | Phosphorylation | score1 | PhosphoSitePlus | |||
K214 | Acetylation | score1 | PhosphoSitePlus | |||
K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
K220 | Ubiquitination | score1 | PhosphoSitePlus | |||
R230 | Methylation | score1 | PhosphoSitePlus | |||
K236 | Ubiquitination | score1 | PhosphoSitePlus | |||
K239 | Acetylation | score1 | PhosphoSitePlus | |||
K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
S241 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S242 | Phosphorylation | score1 | PhosphoSitePlus | |||
S245 | Phosphorylation | score1 | PhosphoSitePlus | |||
T296 | Phosphorylation | score1 | PhosphoSitePlus | |||
K298 | Acetylation | score4 | PhosphoSitePlus UniProt | 22693256, 19608861 | ||
K298 | Ubiquitination | score1 | PhosphoSitePlus | |||
S309 | Phosphorylation | score1 | PhosphoSitePlus | |||
K312 | Ubiquitination | score1 | PhosphoSitePlus | |||
K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
T321 | Phosphorylation | score1 | PhosphoSitePlus | |||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
S332 | Phosphorylation | score1 | PhosphoSitePlus | |||
S333 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S241 | Phosphorylation | score0 | HPRD | 19413330, 20166139, 20068231 | ||
S242 | Phosphorylation | score0 | HPRD | 20068231 | ||
S333 | Phosphorylation | score0 | HPRD | 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S5 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S89 | F89 | Biomuta | DOID:1909 / melanoma [ tcga ] | |
K110 | N110 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S111 | F111 | Biomuta | DOID:8618 / oral cavity cancer [ icgc ] | |
K121 | N121 | Biomuta | DOID:363 / uterine cancer [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ] | |
K149 | N149 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K164 | E164 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K170 | T170 | Biomuta | DOID:1909 / melanoma [ icgc, tcga ] | |
S188 | F188 | Biomuta | DOID:1909 / melanoma [ tcga ] | |
S188 | Y188 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K199 | R199 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
R230 | H230 | Biomuta | DOID:5041 / esophageal cancer [ tcga ] | |
K236 | N236 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] | |
S245 | Y245 | Biomuta | DOID:9256 / colorectal cancer [ icgc, tcga ] | |
K298 | N298 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
S309 | L309 | Biomuta | DOID:1909 / melanoma [ icgc, tcga ] | |
K312 | N312 | Biomuta | DOID:363 / uterine cancer [ cosmic, tcga ] |