Protein Information

Cytoscape View


UniProt AC / UniProt ID P40818 / UBP8_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 8
Gene Name Name: USP8
Synonyms:KIAA0055,UBPY;
Organism Homo sapiens (Human)

PRO ID PR:P40818
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 8 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 8 that is encoded in the genome of human.
Short Label hUSP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40818 (USP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
R51 Methylation PhosphoSitePlus
R54 Methylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T351 Phosphorylation PhosphoSitePlus
S378 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T379 Phosphorylation PhosphoSitePlus
S389 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S400 Phosphorylation PhosphoSitePlus   UniProt 23186163
T410 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S452 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T454 Phosphorylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
T577 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S597 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
K601 Acetylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
Y717 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S718 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18220336, ...25675982, 18669648, 20068231
S719 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T723 Phosphorylation PhosphoSitePlus
T737 Phosphorylation PhosphoSitePlus
T739 Phosphorylation PhosphoSitePlus
Y810 Phosphorylation PhosphoSitePlus
Y842 Phosphorylation PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
T945 Phosphorylation PRO
Y951 Phosphorylation PhosphoSitePlus
K1012 Methylation PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
Y1016 Phosphorylation PhosphoSitePlus
Y1068 Phosphorylation PhosphoSitePlus
Y1106 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S108 Phosphorylation HPRD 20068231
S160 Phosphorylation HPRD 20068231
S378 Phosphorylation HPRD 18669648
S389 Phosphorylation HPRD 18669648, 20068231
S392 Phosphorylation HPRD 17322306, 18669648, 19415658, ...20068231
S434 Phosphorylation HPRD 19651622, 20068231, 17924679
S452 Phosphorylation HPRD 19413330, 18669648, 20068231
T577 Phosphorylation HPRD 19664994
S653 Phosphorylation HPRD 20068231
Y668 Phosphorylation HPRD 20068231
T692 Phosphorylation HPRD 20068231
S716 Phosphorylation HPRD 19651622, 20166139, 20068231, ...18452278
Y717 Phosphorylation HPRD 18669648
S718 Phosphorylation HPRD 20230923, 19664994, 18452278, ...19651622, 18669648, 20166139, 20068231
S719 Phosphorylation HPRD 18767875, 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049634 (hUSP8/Phos:1) pT945 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 L6 Biomuta DOID:263 / kidney cancer [ tcga ]
R54 C54 Biomuta DOID:1324 / lung cancer [ cosmic ]
T351 K351 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T351 A351 Biomuta DOID:1324 / lung cancer [ tcga ]
S434 F434 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S686 A686 Biomuta DOID:263 / kidney cancer [ cosmic ]
S687 Y687 Biomuta DOID:363 / uterine cancer [ tcga ]
T692 A692 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S716 F716 Biomuta DOID:1909 / melanoma [ icgc, tcga ]