iPTMnet Report for P40424 (PBX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40424 / PBX1_HUMAN
Protein Name Pre-B-cell leukemia transcription factor 1
Gene Name Name: PBX1
Synonyms:PRL;
Organism Homo sapiens (Human)

PRO ID PR:P40424
DAG View
PRO Name pre-B-cell leukemia transcription factor 1 (human)
Definition A pre-B-cell leukemia transcription factor 1 that is encoded in the genome of human.
Short Label hPBX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40424 (PBX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K87 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
C220 Methylation IEDB 31844290
Y305 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S379 Phosphorylation HPRD 20068231
S429 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S325 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
Y335 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S126 P126 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S126 L126 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S136 F136 Biomuta DOID:1324 / lung cancer [ cosmic ]
C220 G220 Biomuta DOID:3571 / liver cancer [ cosmic ]
S325 L325 Biomuta DOID:1612 / breast cancer [ cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic ]
T328 A328 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S331 L331 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y335 H335 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y335 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S337 L337 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S337 P337 Biomuta DOID:1324 / lung cancer [ cosmic ]