iPTMnet Report for P40238 (MPL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40238 / TPOR_HUMAN
Protein Name Thrombopoietin receptor precursor
Gene Name Name: MPL
Synonyms:TPOR;
Organism Homo sapiens (Human)

PRO ID PR:P40238
DAG View
PRO Name thrombopoietin receptor (human)
Definition A thrombopoietin receptor that is encoded in the genome of human.
Short Label hMPL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40238 (MPL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S81 Phosphorylation PhosphoSitePlus
N117 N-Glycosylation GlyGen 29741879, 22649382
N298 N-Glycosylation GlyGen 22649382
T546 Phosphorylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus   UniProt 19880496
K573 Ubiquitination PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
Y626 Phosphorylation phospho.ELM   PhosphoSitePlus 9122198
Y631 Phosphorylation phospho.ELM   PhosphoSitePlus 9122198
Site PTM Type PTM Enzyme Score Source PMID
T546 Phosphorylation HPRD 19413330
Y626 Phosphorylation HPRD 9122198
Y631 Phosphorylation HPRD 9122198


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S81 F81 Biomuta DOID:4159 / skin cancer [ cosmic ]
T546 N546 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y591 D591 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y631 C631 Biomuta DOID:10534 / stomach cancer [ cosmic ]