iPTMnet Report for P40227 (CCT6A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40227 / TCPZ_HUMAN
Protein Name T-complex protein 1 subunit zeta
Gene Name Name: CCT6A
Synonyms:CCT6,CCTZ;
Organism Homo sapiens (Human)

PRO ID PR:P40227
DAG View
PRO Name T-complex protein 1 subunit zeta (human)
Definition A T-complex protein 1 subunit zeta that is encoded in the genome of human.
Short Label hCCT6A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40227 (CCT6A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K5 Acetylation PhosphoSitePlus
K5 Methylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
T6 Phosphorylation PhosphoSitePlus
K10 Acetylation PhosphoSitePlus
K10 Sumoylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
R35 Methylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
T43 O-Glycosylation GlyGen 16408927, 33214551, 35138101, ...30397120, 34725712, 34019948, 32870666, 32119511, 36580660, 28510447, 33465208
K45 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K199 Acetylation PhosphoSitePlus   UniProt 19608861
K199 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y229 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K287 Acetylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
R314 Methylation PhosphoSitePlus
K365 Acetylation PhosphoSitePlus   UniProt 19608861
K365 Ubiquitination PhosphoSitePlus
K377 Acetylation PhosphoSitePlus   UniProt 19608861
K377 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
K388 Acetylation PhosphoSitePlus   UniProt 19608861
K388 Ubiquitination PhosphoSitePlus
R396 Methylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
C406 Methylation IEDB 31844290
C406 S-Nitrosylation dbSNO 16648260, 22178444
K424 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S205 Phosphorylation HPRD 19651622, 19664994
Site PTM Type PTM Enzyme Score Source PMID
K58 Ubiquitination PhosphoSitePlus
S160 Phosphorylation HPRD 19651622, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K79 M79 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T82 A82 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S160 N160 Biomuta DOID:1319 / brain cancer [ icgc ]
S205 N205 Biomuta DOID:1319 / brain cancer [ icgc ]
Y229 C229 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y239 H239 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K258 Q258 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R314 C314 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R314 H314 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R314 L314 Biomuta DOID:3571 / liver cancer [ cosmic ]
R396 K396 Biomuta DOID:4159 / skin cancer [ cosmic ]