iPTMnet Report for P40225 (THPO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40225 / TPO_HUMAN
Protein Name Thrombopoietin precursor
Gene Name Name: THPO
Synonyms:MGDF;
Organism Homo sapiens (Human)

PRO ID PR:P40225
DAG View
PRO Name thrombopoietin (human)
Definition A thrombopoietin that is encoded in the genome of human.
Short Label hTHPO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40225 (THPO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 O-Glycosylation GlyGen   UniProt 8942648
S34 Phosphorylation PhosphoSitePlus
T58 O-Glycosylation GlyGen   UniProt 8942648
T58 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
T131 O-Glycosylation GlyGen   UniProt 8942648
T179 O-Glycosylation GlyGen   UniProt 8942648
T180 O-Glycosylation GlyGen   UniProt 8942648
S184 O-Glycosylation GlyGen   UniProt 8942648
N197 N-Glycosylation GlyGen   UniProt 8942648
T205 Phosphorylation PhosphoSitePlus
N206 N-Glycosylation GlyGen   UniProt 8942648
T213 O-Glycosylation GlyGen   UniProt 8942648
S216 Phosphorylation PhosphoSitePlus
N234 N-Glycosylation GlyGen   UniProt 8942648
N255 N-Glycosylation GlyGen   UniProt 8942648
S265 O-Glycosylation GlyGen   UniProt 8942648
Site PTM Type PTM Enzyme Score Source PMID
N197 N-Glycosylation PRO 8942648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T79 S79 Biomuta DOID:1612 / breast cancer [ cosmic ]
N197 K197 Biomuta DOID:1319 / brain cancer [ cosmic ]
S265 L265 Biomuta DOID:1324 / lung cancer [ cosmic ]