iPTMnet Report for P40189 (IL6ST)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40189 / IL6RB_HUMAN
Protein Name Interleukin-6 receptor subunit beta precursor
Gene Name Name: IL6ST
Organism Homo sapiens (Human)

PRO ID PR:P40189
DAG View
PRO Name interleukin-6 receptor subunit beta (human)
Definition An interleukin-6 receptor subunit beta that is encoded in the genome of human.
Short Label hIL6ST
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40189 (IL6ST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N43 N-Glycosylation UniProt 11098061, 20489211
N83 N-Glycosylation UniProt 11098061, 20489211
N131 N-Glycosylation UniProt 11098061
K140 Ubiquitination PhosphoSitePlus
N157 N-Glycosylation UniProt 11098061
K168 Ubiquitination PhosphoSitePlus
N227 N-Glycosylation UniProt 11098061, 20489211, 19159218
Y309 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
N379 N-Glycosylation UniProt 16335952, 11098061
N383 N-Glycosylation UniProt 16335952, 11098061, 20489211
N390 N-Glycosylation UniProt 19139490, 19159218
Y396 Phosphorylation PhosphoSitePlus
N553 N-Glycosylation UniProt 11098061, 20489211
N564 N-Glycosylation UniProt 11098061
K649 Ubiquitination PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus   UniProt 24275569
S667 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569, ...18088087, 20068231
T670 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation phospho.ELM 10661409
K702 Ubiquitination PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
Y759 Phosphorylation phospho.ELM   PhosphoSitePlus 8934572, 9505191
T761 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Y767 Phosphorylation phospho.ELM   PhosphoSitePlus 10661409, 8612579
S780 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S782 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27537522, 15786731, 10811661
T783 Phosphorylation phospho.ELM 18669648
Y814 Phosphorylation phospho.ELM   PhosphoSitePlus 10661409, 8612579
S820 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S824 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
S829 Phosphorylation phospho.ELM   UniProt 17081983
K835 Ubiquitination PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus   UniProt 23186163
K849 Methylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
T890 Phosphorylation Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12361954
T897 Phosphorylation PhosphoSitePlus
Y905 Phosphorylation phospho.ELM   PhosphoSitePlus 10661409, 8612579
T909 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus 12361954
Y915 Phosphorylation phospho.ELM   PhosphoSitePlus 10661409, 8612579
Site PTM Type PTM Enzyme Score Source PMID
S667 Phosphorylation HPRD 19651622, 18088087, 17081983, ...20068231
T670 Phosphorylation HPRD 19651622, 17081983, 20068231
S678 Phosphorylation HPRD 20068231
S710 Phosphorylation HPRD 20068231
S780 Phosphorylation HPRD 18669648
S782 Phosphorylation HPRD 10811661
T783 Phosphorylation HPRD 18669648
S820 Phosphorylation HPRD 17081983, 20068231
S824 Phosphorylation HPRD 20068231
S829 Phosphorylation HPRD 17081983
S839 Phosphorylation HPRD 19664994
T890 Phosphorylation Q05655 (PRKCD) HPRD 12361954
T909 Phosphorylation Q05655 (PRKCD) HPRD 12361954


P40189 (IL6ST) as PTM Enzyme



Substrate Site Score Source PMID
O60674 (JAK2) Y1007 Signor 9716487
O60674 (JAK2) Y1008 Signor 9716487


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N43 T43 Biomuta DOID:1612 / breast cancer [ cosmic ]
N379 S379 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S667 L667 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Y759 H759 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S782 C782 Biomuta DOID:1324 / lung cancer [ tcga ]
S820 G820 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S824 F824 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S838 L838 Biomuta DOID:1909 / melanoma [ icgc, tcga ]