iPTMnet Report for P40189 (IL6ST)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40189 / IL6RB_HUMAN
Protein Name Interleukin-6 receptor subunit beta precursor
Gene Name Name: IL6ST
Organism Homo sapiens (Human)

PRO ID PR:P40189
DAG View
PRO Name interleukin-6 receptor subunit beta (human)
Definition An interleukin-6 receptor subunit beta that is encoded in the genome of human.
Short Label hIL6ST
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40189 (IL6ST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N43 N-Glycosylation GlyGen   UniProt 11098061, 20489211
N83 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 11098061, ...20489211, 24190977
N131 N-Glycosylation GlyGen   UniProt 11098061, 29391424
S133 O-Glycosylation GlyGen 34019948, 35289036
K140 Ubiquitination PhosphoSitePlus
N157 N-Glycosylation GlyGen   UniProt 23090970, 11098061, 29391424, ...24190977
K168 Ubiquitination PhosphoSitePlus
N227 N-Glycosylation GlyGen   UniProt 11098061, 20489211, 19159218
N246 N-Glycosylation GlyGen 29391424
Y309 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
N379 N-Glycosylation GlyGen   UniProt 16335952, 11098061, 29391424, ...23345538
N383 N-Glycosylation GlyGen   UniProt 16335952, 11098061, 20489211
N390 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 23090970, ...29391424, 19139490, 23345538
Y396 Phosphorylation PhosphoSitePlus
N553 N-Glycosylation GlyGen   UniProt 11098061, 20489211, 29391424
T555 O-Glycosylation GlyGen 34019948, 35289036
N564 N-Glycosylation GlyGen   UniProt 11098061
K649 Ubiquitination PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus   UniProt 24275569
S667 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569, ...18088087, 20068231
T670 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation phospho.ELM 10661409
N687 N-Glycosylation GlyGen 29391424
K702 Ubiquitination PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
Y759 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 8934572, 31651330, 16459330, ...9505191
T761 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Y767 Phosphorylation phospho.ELM   PhosphoSitePlus 10661409, 8612579
S780 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S782 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27537522, 27957549, 10811661, ...15786731
T783 Phosphorylation phospho.ELM 18669648
Y814 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 8662591, 10661409, 8612579
N818 N-Glycosylation GlyGen 23345538
S820 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S824 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
S829 Phosphorylation phospho.ELM   UniProt 17081983
K835 Ubiquitination PhosphoSitePlus
S838 Phosphorylation IEDB   PhosphoSitePlus 33936100
S839 Phosphorylation IEDB   PhosphoSitePlus   UniProt 23186163, 33936100
K849 Methylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
T890 Phosphorylation Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12361954
T897 Phosphorylation PhosphoSitePlus
Y905 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 8662591, 33491667, 10661409, ...8612579
T909 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus 12361954
Y915 Phosphorylation phospho.ELM   PhosphoSitePlus 10661409, 8612579
Site PTM Type PTM Enzyme Score Source PMID
N379 N-Glycosylation PRO 23345538
N390 N-Glycosylation PRO 23345538
S667 Phosphorylation HPRD 19651622, 18088087, 17081983, ...20068231
T670 Phosphorylation HPRD 19651622, 17081983, 20068231
S678 Phosphorylation HPRD 20068231
S710 Phosphorylation HPRD 20068231
S780 Phosphorylation HPRD 18669648
S782 Phosphorylation HPRD 10811661
T783 Phosphorylation HPRD 18669648
N818 N-Glycosylation PRO 23345538
S820 Phosphorylation HPRD 17081983, 20068231
S824 Phosphorylation HPRD 20068231
S829 Phosphorylation HPRD 17081983
S839 Phosphorylation HPRD 19664994
T890 Phosphorylation Q05655 (PRKCD) HPRD 12361954
T909 Phosphorylation Q05655 (PRKCD) HPRD 12361954


P40189 (IL6ST) as PTM Enzyme



Substrate Site Score Source PMID
O60674 (JAK2) Y1007 Signor 9716487
O60674 (JAK2) Y1008 Signor 9716487


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P40189 (IL6ST) Y905 P42227 (Stat3) unknown eFIP 33491667


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N43 T43 Biomuta DOID:1612 / breast cancer [ cosmic ]
N131 K131 Biomuta DOID:10534 / stomach cancer [ cosmic ]
N246 K246 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N379 S379 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T555 I555 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S667 L667 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S678 L678 Biomuta DOID:4159 / skin cancer [ cosmic ]
S710 A710 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S710 L710 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y759 H759 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S782 C782 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S820 G820 Biomuta DOID:184 / bone cancer [ cosmic ]
S824 F824 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S829 A829 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S838 L838 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]