iPTMnet Report for P40123 (CAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40123 / CAP2_HUMAN
Protein Name Adenylyl cyclase-associated protein 2
Gene Name Name: CAP2
Organism Homo sapiens (Human)

PRO ID PR:P40123
DAG View
PRO Name adenylyl cyclase-associated protein 2 (human)
Definition An adenylyl cyclase-associated protein 2 that is encoded in the genome of human.
Short Label hCAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40123 (CAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
K186 Methylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S301 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S305 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus   UniProt 24275569
T311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T299 Phosphorylation HPRD 20068231
S301 Phosphorylation HPRD 17287340
S309 Phosphorylation HPRD 20068231
S312 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
A2 S2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T299 I299 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S301 Y301 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T307 I307 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S312 F312 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S315 F315 Biomuta DOID:4159 / skin cancer [ cosmic ]
S315 Y315 Biomuta DOID:2174 / ocular cancer [ cosmic ]
S412 F412 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]