Protein Information

Cytoscape View


UniProt AC / UniProt ID P39748 / FEN1_HUMAN
Protein Name Flap endonuclease 1
Gene Name Name: FEN1
Synonyms:RAD2;
Organism Homo sapiens (Human)

PRO ID PR:P39748
DAG View
PRO Name flap endonuclease 1 (human)
Definition A flap endonuclease 1 that is encoded in the genome of human.
Short Label hFEN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P39748 (FEN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
R19 Methylation PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus   UniProt 19608861
K80 Ubiquitination PhosphoSitePlus
K88 Sumoylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K93 Sumoylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
R100 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
R104 Methylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
C163 S-Nitrosylation dbSNO 26338901
K168 Sumoylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S187 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12853968, 20729856
R192 Methylation PhosphoSitePlus
T195 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S197 Phosphorylation PhosphoSitePlus   UniProt 20068231
K200 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K201 Sumoylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus   UniProt 23186163
K267 Acetylation PhosphoSitePlus
K267 Sumoylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus   UniProt 23186163
K297 Sumoylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K308 Sumoylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K314 Sumoylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus   UniProt 23186163
T336 Phosphorylation PhosphoSitePlus   UniProt 23186163
K345 Methylation PhosphoSitePlus
K345 Sumoylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K354 Acetylation PhosphoSitePlus   UniProt 11430825
K354 Sumoylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus   UniProt 20068231
K375 Acetylation PhosphoSitePlus   UniProt 11430825, 19608861
K375 Sumoylation PhosphoSitePlus
K377 Acetylation PhosphoSitePlus   UniProt 11430825
K380 Acetylation PhosphoSitePlus   UniProt 11430825
Site PTM Type PTM Enzyme Score Source PMID
S187 Phosphorylation P06493 (CDK1) HPRD 12853968
T195 Phosphorylation HPRD 20068231
S197 Phosphorylation HPRD 20068231
S335 Phosphorylation HPRD 20068231
T364 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P39748 (FEN1) S187 P12004 (PCNA) unknown eFIP 20729856


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R19 W19 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R104 Q104 Biomuta DOID:1324 / lung cancer [ cosmic ]
R192 Q192 Biomuta DOID:10534 / stomach cancer [ tcga ]
K254 N254 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S255 I255 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K277 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S329 N329 Biomuta DOID:9256 / colorectal cancer [ tcga ]