Protein Information

Cytoscape View


UniProt AC / UniProt ID P39688 / FYN_MOUSE
Protein Name Tyrosine-protein kinase Fyn
Gene Name Name: Fyn
Organism Mus musculus (Mouse)

PRO ID PR:P39688
DAG View
PRO Name tyrosine-protein kinase Fyn (mouse)
Definition A tyrosine-protein kinase Fyn that is encoded in the genome of mouse.
Short Label mFYN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P39688 (Fyn) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 8655574
S21 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19144319, 20658524
S25 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
Y28 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 9425276, 8144681
Y30 Phosphorylation P39688 (Fyn) RLIMS-P+ 9425276
Y39 Phosphorylation P39688 (Fyn) RLIMS-P+ 9425276
Y91 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus   UniProt 18034455
S186 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K320 Methylation PhosphoSitePlus
K322 Methylation PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation P39688 (Fyn) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16339530, 26224309, 27859601, ...9425276, 8441403
T421 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27527133, 8631859, 26224309, ...16339530, 18034455, 8441403, 19786542
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation phospho.ELM 19144319
Y417 Phosphorylation phospho.ELM 19144319


P39688 (Fyn) as PTM Enzyme



Substrate Site Score Source PMID
B2CXA1 (Gm45915) Y102 PhosphoSitePlus 26901312
P09793 (Ctla4) Y201 PhosphoSitePlus 9973379
P09793 (Ctla4) Y218 PhosphoSitePlus 9973379
P22646 (Cd3e) Y170 PhosphoSitePlus 9312149
P22646 (Cd3e) Y181 PhosphoSitePlus 9312149
P22723 (Gabrg2) Y413 PhosphoSitePlus 20233604
P28867 (Prkcd) Y311 PhosphoSitePlus 18387943
P28867 (Prkcd) Y332 PhosphoSitePlus 18387943
P39688 (Fyn) Y30 RLIMS-P+ 9425276
P39688 (Fyn) Y39 RLIMS-P+ 9425276
P39688 (Fyn) Y420 UniProt 8441403
P49615 (Cdk5) Y15 PhosphoSitePlus 12372285, 18948252
P70315 (Was) Y293 PhosphoSitePlus 14707117
P97813 (Pld2) Y11 phospho.ELM 15282299
P97813 (Pld2) Y14 phospho.ELM 15282299
P97813 (Pld2) Y165 phospho.ELM 15282299
P97813 (Pld2) Y470 phospho.ELM 15282299
Q01097 (Grin2b) Y932 phospho.ELM 11024032
Q01097 (Grin2b) Y1039 phospho.ELM 11024032
Q01097 (Grin2b) Y1070 phospho.ELM 11024032
Q01097 (Grin2b) Y1109 phospho.ELM 11024032
Q01097 (Grin2b) Y1252 phospho.ELM   PhosphoSitePlus 11024032
Q01097 (Grin2b) Y1336 phospho.ELM   PhosphoSitePlus 11024032
Q01097 (Grin2b) Y1472 phospho.ELM   PhosphoSitePlus 16190898, 12451687, 11024032
Q02248 (Ctnnb1) Y142 PhosphoSitePlus 12640114
Q60795 (Nfe2l2) Y568 PhosphoSitePlus 16513647
Q8BM65 (Nyap2) Y277 PhosphoSitePlus 21946561
Q8BM65 (Nyap2) Y300 PhosphoSitePlus 21946561
Q8C863 (Itch) Y381 Signor 16387660
Q91XM9 (Dlg2) Y348 phospho.ELM   PhosphoSitePlus 13129934
Q923U0 (Tom1l1) Y441 PhosphoSitePlus 11711534
Q923U0 (Tom1l1) Y457 PhosphoSitePlus 11711534


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P39688 (Fyn) Y531 P35569 (Irs1) increased_association eFIP 8631859
Phosphorylation P39688 (Fyn) Y531 P06804 (Tnf) decreased_association eFIP 19786542