Protein Information

Cytoscape View


UniProt AC / UniProt ID P38919 / IF4A3_HUMAN
Protein Name Eukaryotic initiation factor 4A-III
Gene Name Name: EIF4A3
Synonyms:DDX48,KIAA0111;
Organism Homo sapiens (Human)

PRO ID PR:P38919
DAG View
PRO Name eukaryotic initiation factor 4A-III (human)
Definition A eukaryotic initiation factor 4A-III that is encoded in the genome of human.
Short Label hEIF4A3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38919 (EIF4A3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692, 20068231
A2 Acetylation UniProt 19413330, 19369195, 21406692, ...22223895, 22814378, 20068231
T3 Phosphorylation PhosphoSitePlus
T4 Phosphorylation HPRD 20068231
T6 Phosphorylation HPRD 20068231
T9 Phosphorylation HPRD   PhosphoSitePlus 20068231
S10 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 20068231
S12 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18691976, 19691289, 19007248, 19651622, 20068231
R14 Methylation PhosphoSitePlus
K19 Sumoylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Methylation PhosphoSitePlus
K60 Sumoylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
T163 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 18847512, ...30784594, 19651622, 18669648, 20068231
K182 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K289 Acetylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K296 Acetylation PhosphoSitePlus   UniProt 19608861
K296 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus   UniProt 19608861
K321 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 K4 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R14 Q14 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:1324 / lung cancer [ cosmic ]