Protein Information

Cytoscape View


UniProt AC / UniProt ID P38646 / GRP75_HUMAN
Protein Name Stress-70 protein, mitochondrial precursor
Gene Name Name: HSPA9
Synonyms:GRP75,HSPA9B,mt-HSP70;
Organism Homo sapiens (Human)

PRO ID PR:P38646
DAG View
PRO Name stress-70 protein, mitochondrial (human)
Definition A stress-70 protein, mitochondrial that is encoded in the genome of human.
Short Label hHSPA9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38646 (HSPA9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
T62 Phosphorylation P33981 (TTK) HPRD   phospho.ELM   PhosphoSitePlus   Signor 17573779, 20068231
S65 Phosphorylation P33981 (TTK) phospho.ELM   PhosphoSitePlus   Signor 17573779
K76 Ubiquitination PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus   UniProt 23186163
K106 Ubiquitination PhosphoSitePlus
T111 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y118 Phosphorylation PhosphoSitePlus
T120 Phosphorylation HPRD   PhosphoSitePlus 20068231
K121 Acetylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus   UniProt 19608861
K135 Ubiquitination PhosphoSitePlus
K138 Acetylation PhosphoSitePlus   UniProt 19608861
K138 Ubiquitination PhosphoSitePlus
K143 Acetylation PhosphoSitePlus   UniProt 19608861
K143 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
S200 Phosphorylation HPRD   PhosphoSitePlus 17525332
T205 Phosphorylation PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
R218 Methylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus   UniProt 19608861
K234 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K288 Acetylation PhosphoSitePlus   UniProt 19608861
K288 Ubiquitination PhosphoSitePlus
K291 Acetylation PhosphoSitePlus
K300 Acetylation PhosphoSitePlus   UniProt 19608861
K300 Ubiquitination PhosphoSitePlus
R307 Methylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
R360 Methylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
K377 Acetylation PhosphoSitePlus
S378 Phosphorylation HPRD   PhosphoSitePlus 20068231
T390 Phosphorylation PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
T398 Phosphorylation PhosphoSitePlus
R405 Methylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus   UniProt 23186163
T462 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
C487 S-Nitrosylation dbSNO 26338901, 16648260, 22178444, ...20140087
K498 Acetylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
R513 Methylation PhosphoSitePlus   UniProt 24129315
S533 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K567 Acetylation PhosphoSitePlus   UniProt 19608861
Y568 Phosphorylation HPRD   PhosphoSitePlus 18083107, 20068231
K595 Acetylation PhosphoSitePlus
K600 Acetylation PhosphoSitePlus
C608 S-Nitrosylation dbSNO 20140087, 22178444
K610 Acetylation PhosphoSitePlus
K612 Acetylation PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
S616 Phosphorylation HPRD   PhosphoSitePlus 20068231
R624 Methylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S638 Phosphorylation HPRD 20068231
S639 Phosphorylation HPRD 20068231
K646 Acetylation PhosphoSitePlus   UniProt 19608861
K646 Ubiquitination PhosphoSitePlus
Y652 Phosphorylation PhosphoSitePlus
K653 Methylation PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
K671 Acetylation PhosphoSitePlus
K675 Acetylation PhosphoSitePlus
K678 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K106 M106 Biomuta DOID:1324 / lung cancer [ cosmic ]
S148 C148 Biomuta DOID:1324 / lung cancer [ tcga ]
K234 T234 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K288 N288 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K300 T300 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S336 Y336 Biomuta DOID:363 / uterine cancer [ tcga ]
K555 N555 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S638 T638 Biomuta DOID:1324 / lung cancer [ tcga ]
S639 F639 Biomuta DOID:1909 / melanoma [ cosmic ]