iPTMnet Report for P38435 (GGCX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P38435 / VKGC_HUMAN
Protein Name Vitamin K-dependent gamma-carboxylase
Gene Name Name: GGCX
Synonyms:GC;
Organism Homo sapiens (Human)

PRO ID PR:P38435
DAG View
PRO Name vitamin K-dependent gamma-carboxylase (human)
Definition A vitamin K-dependent gamma-carboxylase that is encoded in the genome of human.
Short Label hGGCX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38435 (GGCX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692
S7 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K19 Acetylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
N459 N-Glycosylation GlyGen   UniProt 19159218
K515 Ubiquitination PhosphoSitePlus
N550 N-Glycosylation GlyGen   UniProt 19159218
N570 N-Glycosylation GlyGen 24190977
K578 Ubiquitination PhosphoSitePlus
N627 N-Glycosylation GlyGen 29741879, 24190977
T653 O-Glycosylation GlyGen 33214551, 30459171, 34725712, ...34019948, 31492838, 29237092
S695 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231
T10 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K91 N91 Biomuta DOID:363 / uterine cancer [ icgc ]
K318 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K445 R445 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
N459 D459 Biomuta DOID:3565 / meningioma [ cosmic ]