iPTMnet Report for P38398 (BRCA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P38398 / BRCA1_HUMAN
Protein Name Breast cancer type 1 susceptibility protein
Gene Name Name: BRCA1
Synonyms:RNF53;
Organism Homo sapiens (Human)

PRO ID PR:P38398
DAG View
PRO Name breast cancer type 1 susceptibility protein (human)
Definition A breast cancer type 1 susceptibility protein that is encoded in the genome of human.
Short Label hBRCA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38398 (BRCA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Sumoylation PRO
M1 Acetylation UniProt 22814378
K32 Ubiquitination PhosphoSitePlus
S36 Phosphorylation RLIMS-P 25223785
K38 Ubiquitination PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K109 Sumoylation PRO   PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
K119 Sumoylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
N247 N-Glycosylation GlyGen 29671580
K294 Ubiquitination PhosphoSitePlus
S308 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18026198, 14990569
S308 Phosphorylation O14965 (AURKA) neXtProt   PhosphoSitePlus   Signor 14990569
K309 Ubiquitination PhosphoSitePlus
K339 Sumoylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
S395 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S398 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S403 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S405 Phosphorylation phospho.ELM 18669648
S423 Phosphorylation PhosphoSitePlus   UniProt 20068231
S425 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus   UniProt 23186163
K443 Sumoylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K459 Sumoylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
T509 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10542266, 20085797, 17428466
T509 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 10542266, 20085797, 17428466
S510 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus   UniProt 23186163
K566 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus   RLIMS-P 26884712
T617 Phosphorylation PhosphoSitePlus
S632 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 23704879, 17334399
S632 Phosphorylation P11802 (CDK4) neXtProt   PhosphoSitePlus   Signor 17334399
S647 Phosphorylation PhosphoSitePlus
K654 Sumoylation PhosphoSitePlus
S694 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20085797, 23186163, 26884712, ...20068231
S694 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 20085797
K701 Ubiquitination PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus   UniProt 23186163
K711 Ubiquitination PhosphoSitePlus
K734 Sumoylation PhosphoSitePlus
K739 Sumoylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
S753 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S803 Phosphorylation PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
K918 Sumoylation PhosphoSitePlus
T967 Phosphorylation PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
Y978 Phosphorylation PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
S988 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14701743, 12427729, 33397362, ...10724175, 35409089, 34998176, 20364141, 17007555, 18804494, 12111733, 24492479
S988 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor 14701743, 10724175
S988 Phosphorylation Q683Z8 (CHK2) phospho.ELM 14701743, 12111733
S1007 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1050 Phosphorylation PhosphoSitePlus
K1079 Acetylation PhosphoSitePlus
K1079 Sumoylation PhosphoSitePlus
S1101 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23704879, 11114888
S1143 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor 11114888
S1164 Phosphorylation PhosphoSitePlus   RLIMS-P 26745677
S1164 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26745677
K1171 Ubiquitination PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
K1179 Ubiquitination PhosphoSitePlus
S1187 Phosphorylation PhosphoSitePlus
S1189 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19683496, 26745677, 19809577, ...10550055, 23186163
S1189 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 19683496, 10550055
S1189 Phosphorylation Q13315 (ATM) PhosphoSitePlus 10550055
S1191 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 19683496, 23186163, 26745677
S1191 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 19683496
T1194 Phosphorylation PhosphoSitePlus
S1211 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1212 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1218 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S1239 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1245 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1253 Phosphorylation PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
K1264 Ubiquitination PhosphoSitePlus
S1266 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation PhosphoSitePlus
K1278 Ubiquitination PhosphoSitePlus
S1280 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11114888, 19809577
S1280 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor 11114888
S1286 Phosphorylation PhosphoSitePlus
T1289 Phosphorylation PhosphoSitePlus
S1298 Phosphorylation neXtProt 10608806
S1298 Phosphorylation Q13535 (ATR) neXtProt 10608806
S1328 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1330 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 17525332, 10550055
S1330 Phosphorylation Q13315 (ATM) phospho.ELM   Signor 10550055
S1336 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692, 17081983, ...20068231
S1342 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 21406692, 20068231
S1377 Phosphorylation RLIMS-P 26745677
S1387 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10608806, 19622773, 10866324, ...25879655, 11114888, 11278964, 25939603, 12183412
S1387 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19622773, 10866324, 10608806, ...11278964, 12183412
S1387 Phosphorylation Q13535 (ATR) neXtProt   Signor 10608806, 11278964
T1394 Phosphorylation PhosphoSitePlus   Signor   UniProt 11114888
T1394 Phosphorylation Q13535 (ATR) Signor 11114888
S1423 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28879638, 12427729, 24746700, ...14701743, 31663018, 23346553, 16322207, 15159397, 10866324, 31940810, 25879655, 11114888, 11278964, 25939603, 10550055
S1423 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10866324, 11278964, 10550055
S1423 Phosphorylation Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11114888, 11278964
S1457 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24845084, 17525332, 23346553, ...10550055, 10866324, 25879655, 11114888, 28035057, 11278964
S1457 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 10866324, 11278964, 10550055
S1457 Phosphorylation Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11114888, 11278964
S1460 Phosphorylation PhosphoSitePlus
S1466 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17525332, 10608806, 10550055
S1466 Phosphorylation Q13315 (ATM) phospho.ELM   Signor 10550055
S1466 Phosphorylation Q13535 (ATR) neXtProt 10608806
S1473 Phosphorylation PhosphoSitePlus
K1476 Ubiquitination PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
S1483 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus
S1497 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10373534, 19683496, 26745677, ...10550055
S1497 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 19683496, 10550055
S1497 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 10373534, 19683496, 10550055
S1497 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   Signor 19683496, 10550055
S1499 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1503 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus
S1524 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14701743, 12427729, 15096610, ...10550055, 24845084, 31663018, 21118815, 16322207, 17525332, 15159397, 19622773, 23128816, 19176521, 25879655, 21144835, 21919919, 19428384, 11278964, 29439343
S1524 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11278964, 10550055
S1524 Phosphorylation Q13535 (ATR) phospho.ELM   PhosphoSitePlus 11278964
S1542 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24845084, 23186163, 18220336, ...23704879, 10550055, 21338495
S1542 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 10550055
T1548 Phosphorylation PhosphoSitePlus
T1550 Phosphorylation PhosphoSitePlus
Y1552 Phosphorylation PhosphoSitePlus   RLIMS-P 26513018, 29156836
Y1552 Phosphorylation P42685 (FRK) PhosphoSitePlus 26513018
S1572 Phosphorylation PhosphoSitePlus 10403822
S1572 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 10403822
S1577 Phosphorylation PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
T1619 Phosphorylation PhosphoSitePlus
K1636 Ubiquitination PhosphoSitePlus
S1642 Phosphorylation PhosphoSitePlus
K1667 Ubiquitination PhosphoSitePlus
T1677 Phosphorylation PhosphoSitePlus
T1681 Phosphorylation PhosphoSitePlus
C1697 Methylation IEDB 31844290
T1700 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T1720 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T1777 Phosphorylation PhosphoSitePlus
S1790 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 20068231, 18452278
N247 N-Glycosylation PRO 29671580
S308 Phosphorylation HPRD 14990569
S308 Phosphorylation O14965 (AURKA) HPRD 14990569
S395 Phosphorylation HPRD 18669648
S398 Phosphorylation HPRD 18669648, 18452278
S403 Phosphorylation HPRD 18669648, 18452278
S405 Phosphorylation HPRD 18669648
S423 Phosphorylation HPRD 20068231, 18452278
S426 Phosphorylation HPRD 20068231, 18452278
S434 Phosphorylation HPRD 20068231
T509 Phosphorylation HPRD   PRO 10542266
T509 Phosphorylation P31749 (AKT1) HPRD 10542266
S694 Phosphorylation HPRD 20068231, 18452278
S753 Phosphorylation HPRD 18669648, 20068231
S988 Phosphorylation HPRD 10724175, 12111733
S988 Phosphorylation O96017 (CHEK2) HPRD 10724175, 12111733
S1007 Phosphorylation HPRD 20068231, 18452278
S1009 Phosphorylation HPRD 18452278
S1143 Phosphorylation HPRD 11114888
S1143 Phosphorylation Q13535 (ATR) HPRD 11114888
S1164 Phosphorylation HPRD 20068231
S1187 Phosphorylation HPRD 19651622, 20068231
S1189 Phosphorylation HPRD 19651622, 20068231, 10550055
S1189 Phosphorylation Q13315 (ATM) HPRD 19651622, 20068231, 10550055
S1191 Phosphorylation HPRD 19651622, 20068231
T1196 Phosphorylation HPRD 20068231
Y1202 Phosphorylation HPRD 20068231
S1211 Phosphorylation HPRD 18669648, 17081983, 20068231
S1212 Phosphorylation HPRD 18669648, 17081983, 20068231
S1217 Phosphorylation HPRD 18669648, 17081983, 20068231
S1218 Phosphorylation HPRD 18669648, 17081983, 20068231
S1239 Phosphorylation HPRD 17525332
S1245 Phosphorylation HPRD 17525332
S1280 Phosphorylation HPRD 11114888
S1280 Phosphorylation Q13535 (ATR) HPRD 11114888
S1286 Phosphorylation HPRD 20068231
S1328 Phosphorylation HPRD 19651622, 20068231, 18452278
S1330 Phosphorylation HPRD 10550055
S1330 Phosphorylation Q13315 (ATM) HPRD 10550055
S1336 Phosphorylation HPRD 19651622, 17525332, 20068231, ...18452278
S1342 Phosphorylation HPRD 17525332, 20068231, 18452278
S1387 Phosphorylation HPRD 11114888, 11278964
S1387 Phosphorylation Q13315 (ATM) HPRD 11278964
S1387 Phosphorylation Q13535 (ATR) HPRD 11114888
T1394 Phosphorylation HPRD 11114888
T1394 Phosphorylation Q13535 (ATR) HPRD 11114888
S1423 Phosphorylation HPRD   PRO 15254237, 15159397, 10866324, ...10550055, 11114888, 11278964
S1423 Phosphorylation Q13315 (ATM) HPRD 15159397, 10866324, 11278964, ...10550055
S1423 Phosphorylation Q13535 (ATR) HPRD 11114888, 15159397, 11278964
S1457 Phosphorylation HPRD 11114888, 10866324, 11278964, ...10550055
S1457 Phosphorylation Q13315 (ATM) HPRD 10866324, 11278964, 10550055
S1457 Phosphorylation Q13535 (ATR) HPRD 11114888, 11278964
S1460 Phosphorylation HPRD 19651622, 20068231
S1466 Phosphorylation HPRD 10550055
S1466 Phosphorylation Q13315 (ATM) HPRD 10550055
S1497 Phosphorylation HPRD 10373534
S1497 Phosphorylation P24941 (CDK2) HPRD 10373534
S1499 Phosphorylation HPRD 17081983
S1524 Phosphorylation HPRD 11278964, 20068231
S1524 Phosphorylation Q13315 (ATM) HPRD 11278964, 20068231
S1524 Phosphorylation Q13535 (ATR) HPRD 11278964, 20068231
S1542 Phosphorylation HPRD 20068231, 10550055
S1542 Phosphorylation Q13315 (ATM) HPRD 20068231, 10550055
S1572 Phosphorylation HPRD 10403822
S1572 Phosphorylation P68400 (CSNK2A1) HPRD 10403822
S1577 Phosphorylation HPRD 20068231
T1700 Phosphorylation HPRD 17525332
T1720 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 20068231, 18452278
S284 Phosphorylation HPRD 11278964
S284 Phosphorylation Q13315 (ATM) HPRD 11278964
T291 Phosphorylation HPRD 11114888
T291 Phosphorylation Q13535 (ATR) HPRD 11114888
S320 Phosphorylation HPRD 11114888, 10550055
S320 Phosphorylation Q13315 (ATM) HPRD 10550055
S320 Phosphorylation Q13535 (ATR) HPRD 11114888
S353 Phosphorylation HPRD 11114888, 10550055
S353 Phosphorylation Q13315 (ATM) HPRD 10550055
S353 Phosphorylation Q13535 (ATR) HPRD 11114888
S356 Phosphorylation HPRD 19651622, 20068231
S362 Phosphorylation HPRD 17525332
S393 Phosphorylation HPRD 10373534
S393 Phosphorylation P24941 (CDK2) HPRD 10373534
S395 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 20068231, 10550055
S420 Phosphorylation Q13315 (ATM) HPRD 20068231, 10550055
S438 Phosphorylation HPRD 20068231, 10550055
S438 Phosphorylation Q13315 (ATM) HPRD 20068231, 10550055
S468 Phosphorylation HPRD 10403822
S468 Phosphorylation P67870 (CSNK2B) HPRD 10403822
S473 Phosphorylation HPRD 20068231
T596 Phosphorylation HPRD 17525332
T616 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 20068231, 18452278
S284 Phosphorylation HPRD 11278964
S284 Phosphorylation Q13315 (ATM) HPRD 11278964
T291 Phosphorylation HPRD 11114888
T291 Phosphorylation Q13535 (ATR) HPRD 11114888
S320 Phosphorylation HPRD 11114888, 15159397, 10550055
S320 Phosphorylation Q13315 (ATM) HPRD 15159397, 10550055
S320 Phosphorylation Q13535 (ATR) HPRD 11114888, 15159397
S356 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S362 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S420 Phosphorylation HPRD 20068231
S438 Phosphorylation HPRD 20068231
S473 Phosphorylation HPRD 20068231
T596 Phosphorylation HPRD 17525332
T616 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 20068231, 18452278
S395 Phosphorylation HPRD 18669648
S398 Phosphorylation HPRD 18669648, 18452278
S403 Phosphorylation HPRD 18669648, 18452278
S405 Phosphorylation HPRD 18669648
S423 Phosphorylation HPRD 20068231, 18452278
S426 Phosphorylation HPRD 20068231, 18452278
S434 Phosphorylation HPRD 20068231
T509 Phosphorylation HPRD 10542266
T509 Phosphorylation P31749 (AKT1) HPRD 10542266
S694 Phosphorylation HPRD 20068231, 18452278
S753 Phosphorylation HPRD 18669648, 20068231
S988 Phosphorylation HPRD 10724175
S988 Phosphorylation O96017 (CHEK2) HPRD 10724175
S1007 Phosphorylation HPRD 20068231, 18452278
S1009 Phosphorylation HPRD 18452278
S1143 Phosphorylation HPRD 11114888
S1143 Phosphorylation Q13535 (ATR) HPRD 11114888
S1164 Phosphorylation HPRD 20068231
S1187 Phosphorylation HPRD 19651622, 20068231
S1189 Phosphorylation HPRD 19651622, 20068231, 10550055
S1189 Phosphorylation Q13315 (ATM) HPRD 19651622, 20068231, 10550055
S1191 Phosphorylation HPRD 19651622, 20068231
T1196 Phosphorylation HPRD 20068231
Y1202 Phosphorylation HPRD 20068231
S1211 Phosphorylation HPRD 18669648, 17081983, 20068231
S1212 Phosphorylation HPRD 18669648, 17081983, 20068231
S1217 Phosphorylation HPRD 18669648, 17081983, 20068231
S1218 Phosphorylation HPRD 18669648, 17081983, 20068231
S1239 Phosphorylation HPRD 17525332
S1245 Phosphorylation HPRD 17525332
S1280 Phosphorylation HPRD 11114888
S1280 Phosphorylation Q13535 (ATR) HPRD 11114888
S1286 Phosphorylation HPRD 20068231
S1328 Phosphorylation HPRD 19651622, 20068231, 18452278
S1330 Phosphorylation HPRD 10550055
S1330 Phosphorylation Q13315 (ATM) HPRD 10550055
S1336 Phosphorylation HPRD 19651622, 17525332, 20068231, ...18452278
S1342 Phosphorylation HPRD 17525332, 20068231, 18452278
S1387 Phosphorylation HPRD 11278964
S1387 Phosphorylation Q13315 (ATM) HPRD 11278964
T1394 Phosphorylation HPRD 11114888
T1394 Phosphorylation Q13535 (ATR) HPRD 11114888
S1423 Phosphorylation HPRD 15159397, 11114888, 10550055
S1423 Phosphorylation Q13315 (ATM) HPRD 15159397, 10550055
S1423 Phosphorylation Q13535 (ATR) HPRD 11114888, 15159397
S1481 Phosphorylation HPRD 19651622, 20068231
S1545 Phosphorylation HPRD 20068231
S1563 Phosphorylation HPRD 20068231
S1598 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 20068231, 18452278
S348 Phosphorylation HPRD 18669648
S351 Phosphorylation HPRD 18669648, 18452278
S356 Phosphorylation HPRD 18669648, 18452278
S358 Phosphorylation HPRD 18669648
S376 Phosphorylation HPRD 20068231, 18452278
S379 Phosphorylation HPRD 20068231, 18452278
S387 Phosphorylation HPRD 20068231
T462 Phosphorylation HPRD 10542266
T462 Phosphorylation P31749 (AKT1) HPRD 10542266
S647 Phosphorylation HPRD 20068231, 18452278
S706 Phosphorylation HPRD 18669648, 20068231
S941 Phosphorylation HPRD 10724175
S941 Phosphorylation O96017 (CHEK2) HPRD 10724175
S960 Phosphorylation HPRD 20068231, 18452278
S962 Phosphorylation HPRD 18452278
S1096 Phosphorylation HPRD 11114888
S1096 Phosphorylation Q13535 (ATR) HPRD 11114888
S1117 Phosphorylation HPRD 20068231
S1140 Phosphorylation HPRD 19651622, 20068231
S1142 Phosphorylation HPRD 19651622, 20068231, 10550055
S1142 Phosphorylation Q13315 (ATM) HPRD 19651622, 20068231, 10550055
S1144 Phosphorylation HPRD 19651622, 20068231
T1149 Phosphorylation HPRD 20068231
Y1155 Phosphorylation HPRD 20068231
S1164 Phosphorylation HPRD 18669648, 17081983, 20068231
S1165 Phosphorylation HPRD 18669648, 17081983, 20068231
S1170 Phosphorylation HPRD 18669648, 17081983, 20068231
S1171 Phosphorylation HPRD 18669648, 17081983, 20068231
S1192 Phosphorylation HPRD 17525332
S1198 Phosphorylation HPRD 17525332
S1233 Phosphorylation HPRD 11114888
S1233 Phosphorylation Q13535 (ATR) HPRD 11114888
S1239 Phosphorylation HPRD 20068231
S1281 Phosphorylation HPRD 19651622, 20068231, 18452278
S1283 Phosphorylation HPRD 10550055
S1283 Phosphorylation Q13315 (ATM) HPRD 10550055
S1289 Phosphorylation HPRD 19651622, 17525332, 20068231, ...18452278
S1295 Phosphorylation HPRD 17525332, 20068231, 18452278
S1340 Phosphorylation HPRD 11278964
S1340 Phosphorylation Q13315 (ATM) HPRD 11278964
T1347 Phosphorylation HPRD 11114888
T1347 Phosphorylation Q13535 (ATR) HPRD 11114888
S1376 Phosphorylation HPRD 11114888, 10550055
S1376 Phosphorylation Q13315 (ATM) HPRD 10550055
S1376 Phosphorylation Q13535 (ATR) HPRD 11114888
S1410 Phosphorylation HPRD 11114888, 10550055
S1410 Phosphorylation Q13315 (ATM) HPRD 10550055
S1410 Phosphorylation Q13535 (ATR) HPRD 11114888
S1413 Phosphorylation HPRD 19651622, 20068231
S1419 Phosphorylation HPRD 17525332
S1450 Phosphorylation HPRD 10373534
S1450 Phosphorylation P24941 (CDK2) HPRD 10373534
S1452 Phosphorylation HPRD 17081983
S1477 Phosphorylation HPRD 20068231, 10550055
S1477 Phosphorylation Q13315 (ATM) HPRD 20068231, 10550055
S1495 Phosphorylation HPRD 20068231, 10550055
S1495 Phosphorylation Q13315 (ATM) HPRD 20068231, 10550055
S1525 Phosphorylation HPRD 10403822
S1525 Phosphorylation P67870 (CSNK2B) HPRD 10403822
S1530 Phosphorylation HPRD 20068231
T1653 Phosphorylation HPRD 17525332
T1673 Phosphorylation HPRD 17525332


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046511 (hBRCA1/Phos:2) pS1387,pS1423,pS1457,pS1524 PRO
PR:000046512 (hBRCA1/Phos:3) pS988,pS1387,pS1423,pS1457,pS1524 PRO
PR:000046513 (hBRCA1/Sumo:1) suK109 PRO
PR:000046514 (hBRCA1/SumoLys+) su PRO
PR:000045770 (hBRCA1/iso:1/Phos:1) pT509 PRO 10542266
PR:000049803 (hBRCA1/iso:1/Phos:2) pS1423 PRO 15254237


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q86YC2 (PALB2) S64 P38398 (BRCA1) inhibited_association eFIP 28858227
Phosphorylation Q8WXE1 (ATRIP) S239 P38398 (BRCA1) unknown eFIP 17616665
Phosphorylation Q99708 (RBBP8) S327 P38398 (BRCA1) unknown eFIP 23468639
Phosphorylation Q99708 (RBBP8) S327 P38398 (BRCA1) unknown eFIP 24832651
Phosphorylation Q99708 (RBBP8) S327 P38398 (BRCA1) unknown eFIP 28132842


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P38398-5 (hBRCA1/iso:5) Interaction PR:Q92560 (hBAP1) PRO 9528852


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 P36 Biomuta DOID:4159 / skin cancer [ cosmic ]
K38 N38 Biomuta DOID:1612 / breast cancer [ cosmic ]
K50 R50 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K50 T50 Biomuta DOID:1612 / breast cancer [ cosmic ]
K56 T56 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S67 T67 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S114 T114 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T164 I164 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S184 C184 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S186 Y186 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K223 N223 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S284 F284 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T291 I291 Biomuta DOID:1324 / lung cancer [ cosmic ]
K309 Q309 Biomuta DOID:1612 / breast cancer [ cosmic ]
S320 R320 Biomuta DOID:1324 / lung cancer [ cosmic ]
K357 Q357 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S362 I362 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S362 C362 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S369 Y369 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, cosmic, cosmic ]
S369 F369 Biomuta DOID:3571 / liver cancer [ cosmic ]
S379 L379 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S387 N387 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S393 P393 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S395 F395 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S426 L426 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S434 N434 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S438 F438 Biomuta DOID:1324 / lung cancer [ cosmic ]
K443 E443 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S451 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S473 P473 Biomuta DOID:1612 / breast cancer [ cosmic ]
S510 L510 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K519 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T616 I616 Biomuta DOID:8618 / oral cavity cancer [ cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, cosmic ]
T616 A616 Biomuta DOID:3565 / meningioma [ cosmic ]
S647 N647 Biomuta DOID:1612 / breast cancer [ cosmic ]
K654 T654 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S694 N694 Biomuta DOID:1612 / breast cancer [ cosmic ]
S708 C708 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S708 F708 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S741 F741 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S741 Y741 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K820 E820 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S868 L868 Biomuta DOID:1612 / breast cancer [ cosmic ]
S941 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S960 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S962 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T967 I967 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y978 H978 Biomuta DOID:363 / uterine cancer [ cosmic ]
S988 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1007 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1009 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1050 N1050 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1101 R1101 Biomuta DOID:363 / uterine cancer [ icgc ]
S1164 F1164 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1165 P1165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1198 N1198 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1211 F1211 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1212 P1212 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1239 T1239 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1245 N1245 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1254 T1254 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1264 N1264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1278 Q1278 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1286 T1286 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1295 L1295 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1340 F1340 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1342 L1342 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1347 I1347 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1376 R1376 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1387 F1387 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T1394 I1394 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1419 I1419 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1419 C1419 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1423 R1423 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1450 P1450 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1452 F1452 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S1466 I1466 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1466 C1466 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1473 Y1473 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1473 F1473 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1476 R1476 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1483 C1483 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1495 F1495 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1497 P1497 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1499 F1499 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S1503 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1530 P1530 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1542 F1542 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1548 M1548 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1563 F1563 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1577 P1577 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1598 P1598 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1613 G1613 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ] DOID:3277 / thymus cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11615 / penile cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T1619 S1619 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K1667 T1667 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1673 A1673 Biomuta DOID:3565 / meningioma [ cosmic ]
T1673 I1673 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
C1697 R1697 Biomuta DOID:1612 / breast cancer [ cosmic ]
C1697 F1697 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1720 I1720 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1720 A1720 Biomuta DOID:3565 / meningioma [ cosmic ]