iPTMnet Report for P38111 (MEC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P38111 / ATR_YEAST
Protein Name Serine/threonine-protein kinase MEC1
Gene Name Name: MEC1
Synonyms:ESR1,SAD3;OrderedLocusNames:YBR136W;ORFNames:YBR1012;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

PRO ID PR:P38111
DAG View
PRO Name serine/threonine-protein kinase MEC1 (yeast)
Definition A serine/threonine-protein kinase ATR that is encoded in the genome of yeast.
Short Label yMEC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P38111 (MEC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation SGD 33481703
S37 Phosphorylation BioGRID   SGD 23749301, 18407956, 33491328
S38 Phosphorylation BioGRID   SGD 33481703, 17563356, 18407956, ...23749301, 20190278, 32597660, 33491328
S38 Phosphorylation P38110 (TEL1) BioGRID 20190278, 17563356, 18407956
S38 Phosphorylation P38111 (MEC1) BioGRID 20190278, 17563356, 18407956
T73 Phosphorylation SGD 22031224
Y117 Phosphorylation SGD 22031224
K168 Sumoylation SGD 33502312
T336 Phosphorylation BioGRID 14595109
S378 Phosphorylation RLIMS-P 20061370
S990 Phosphorylation SGD 22031224
T994 Phosphorylation SGD 22031224
S1964 Phosphorylation SGD 33491328, 31340146
S1991 Phosphorylation SGD 34569643
S1994 Phosphorylation BioGRID   SGD 19779198


P38111 (MEC1) as PTM Enzyme



Substrate Site Score Source PMID
P02294 (HTB2) T129 BioGRID 20190278
P07273 (DST1) S116 BioGRID 19779198, 20190278, 18407956
P11978 (SIR4) S692 BioGRID 20190278, 18407956
P14164 (ABF1) S193 BioGRID 21177495, 17563356, 18407956
P14737 (RAD9) S989 BioGRID 15972895, 17563356, 18407956
P14922 (CYC8) S780 BioGRID 17563356
P15436 (POL3) S56 BioGRID 17563356
P15992 (HSP26) S208 BioGRID 19684113, 20190278, 11875433, ...18407956, 19779198
P15992 (HSP26) S211 BioGRID 19684113, 20190278, 11875433, ...18407956, 19779198
P16140 (VMA2) S511 BioGRID 19795423, 19823750, 17563356, ...17330950, 20702584, 18407956, 19779198, 19684113, 21126336
P16861 (PFK1) S3 BioGRID 20190278, 21126336, 18407956
P17106 (CBF1) S45 BioGRID 19795423, 19823750, 17563356, ...18407956, 19779198, 20190278, 19684113
P17106 (CBF1) S48 BioGRID 19795423, 19823750, 17563356, ...18407956, 19779198, 20190278, 19684113, 21177495
P17629 (HPR1) S675 BioGRID 20190278, 19795423, 17563356, ...18407956, 19823750
P20050 (HOP1) S22 BioGRID 18329363
P20050 (HOP1) S69 BioGRID 18329363
P20050 (HOP1) T181 BioGRID 18329363
P20050 (HOP1) S298 BioGRID 18329363
P20050 (HOP1) S311 BioGRID 18329363
P20050 (HOP1) T318 BioGRID 18329363
P20050 (HOP1) S454 BioGRID 18329363
P20050 (HOP1) T547 BioGRID 18329363
P22216 (RAD53) S485 BioGRID 16085488, 20190278
P22216 (RAD53) S489 BioGRID 16085488, 20190278, 15972895
P22336 (RFA1) S178 BioGRID 19795423, 19823750, 17563356, ...20702584, 18407956, 19779198, 14642562, 20190278, 19684113, 21177495
P22579 (SIN3) S1126 BioGRID 20190278
P22943 (HSP12) S21 BioGRID 19795423, 19823750, 17563356, ...18407956, 17287358, 19779198, 20190278, 21177495
P25588 (MRC1) T90 BioGRID 12865299, 19515819
P25588 (MRC1) T123 BioGRID 12865299, 19515819, 18407956
P25588 (MRC1) T151 BioGRID 12865299, 19515819
P25588 (MRC1) S164 BioGRID 12865299, 19515819
P25588 (MRC1) T179 BioGRID 12865299, 19515819
P25588 (MRC1) S189 BioGRID 20190278, 12865299, 19515819
P25588 (MRC1) T242 BioGRID 12865299, 19515819
P25588 (MRC1) T272 BioGRID 12865299, 19515819
P25588 (MRC1) S434 BioGRID 12865299, 19515819, 18407956
P25588 (MRC1) T653 BioGRID 12865299
P25588 (MRC1) T882 BioGRID 12865299
P25588 (MRC1) S965 BioGRID 12865299, 18407956
P25635 (PWP2) S664 BioGRID 19779198, 20190278, 18407956
P26755 (RFA3) S34 BioGRID 20190278
P29539 (RIF1) S1351 BioGRID 17563356
P31111 (ZIP1) S75 BioGRID 20951350
P32499 (NUP2) S399 BioGRID 17563356
P32523 (PRP19) S141 BioGRID 19779198, 20190278, 21177495, ...17563356, 18407956
P32591 (SWI3) S88 BioGRID 21126336, 20190278, 21177495, ...17563356, 18407956
P32591 (SWI3) S185 BioGRID 19779198, 20190278, 19795423, ...19823750, 18407956
P32597 (STH1) T1166 BioGRID 20190278, 21126336, 18407956
P32597 (STH1) S1172 BioGRID 20190278
P32598 (GLC7) S3 BioGRID 20190278, 20489023
P32628 (RAD23) S121 BioGRID 20190278, 21177495, 18407956
P32774 (TOA2) S95 BioGRID 19779198, 20190278, 18407956
P32774 (TOA2) S102 BioGRID 20190278, 17563356, 18407956
P32774 (TOA2) S104 BioGRID 20190278
P32783 (ABD1) S12 BioGRID 20190278
P32797 (CDC13) S225 BioGRID 17108359
P32797 (CDC13) S249 BioGRID 17108359
P32797 (CDC13) S255 BioGRID 17108359, 20837994
P32797 (CDC13) S306 RLIMS-P+ 17108359
P33322 (CBF5) S395 BioGRID 19795423, 19823750, 21126336, ...20702584, 19779198, 20190278, 21177495
P33322 (CBF5) S399 BioGRID 19795423, 19823750, 17563356, ...20702584, 18407956, 19779198, 20190278, 21177495
P35177 (SPT7) T78 BioGRID 19779198, 20190278, 17563356, ...18407956
P35817 (BDF1) S630 BioGRID 20190278
P38111 (MEC1) S38 BioGRID 20190278, 17563356, 18407956
P38193 (PSY4) S415 BioGRID 20190278, 18407956
P38333 (ENP1) S172 BioGRID 19779198, 17563356, 18407956
P38439 (LEO1) S34 BioGRID 17563356
P38439 (LEO1) S339 BioGRID 20190278, 17563356
P38772 (BCD1) S330 BioGRID 17330950, 20190278
P38781 (RSC30) S815 BioGRID 20190278
P38850 (RTT107) S743 BioGRID 14988729, 17330950, 20190278
P38850 (RTT107) S800 BioGRID 19779198, 20190278, 18407956
P38850 (RTT107) S806 BioGRID 14988729, 19779198, 20190278, ...17563356, 18407956
P38859 (DNA2) S287 BioGRID 20190278
P38920 (MLH1) S441 BioGRID 17563356, 18407956
P39009 (DUN1) S176 BioGRID 12967660, 17114794
P39009 (DUN1) S274 BioGRID 12967660, 17114794
P39009 (DUN1) S345 BioGRID 12967660, 17114794
P40340 (YTA7) S1142 BioGRID 19795423, 19823750, 17563356, ...20489023, 20702584, 21126336, 18407956, 19779198, 20190278, 21177495, 15972895
P40467 (ASG1) S166 BioGRID 20190278, 17563356, 18407956
P40856 (SAP185) S14 BioGRID 20190278
P43579 (IES1) S36 BioGRID 20190278, 18407956
P46151 (MET12) S120 BioGRID 20190278, 18407956
P46676 (SUM1) S712 BioGRID 19779198, 20190278, 17563356, ...18407956
P46946 (SAE2) S73 BioGRID 18670132, 16861895
P46946 (SAE2) T90 BioGRID 18670132, 16861895
P46946 (SAE2) S249 BioGRID 18670132, 16861895
P46946 (SAE2) T279 BioGRID 18670132, 16861895
P46946 (SAE2) S289 BioGRID 18670132, 16861895
P46957 (POL31) S20 BioGRID 20190278, 18407956
P47134 (BIR1) S751 BioGRID 20190278, 18407956
P48581 (RAD17) S357 BioGRID 19795423, 17563356, 18407956, ...19823750
P52910 (ACS2) S679 BioGRID 20190278, 18407956
P53115 (INO80) S102 BioGRID 20190278
P53165 (SGF73) S22 BioGRID 20190278, 18407956
P53303 (ZPR1) T407 BioGRID 20190278, 18407956
P53312 (LSC2) S276 BioGRID 20190278, 18407956
P53438 (SOK2) S719 BioGRID 17563356
P53920 (NMA111) S993 BioGRID 20190278
P54838 (DAK1) S563 BioGRID 20190278, 18407956
P69850 (DAD3) S43 BioGRID 20190278
Q00772 (SLT2) S428 BioGRID 20489023, 18407956, 19805511
Q02206 (RSC4) S545 BioGRID 20190278, 18407956
Q02574 (MEC3) S452 BioGRID 17563356, 18407956
Q03761 (TAF12) S325 BioGRID 20190278, 18407956
Q03834 (MSH6) S102 BioGRID 20190278, 17563356, 18407956
Q03834 (MSH6) S130 BioGRID 20190278, 17563356, 18407956, ...17287358
Q03834 (MSH6) T451 BioGRID 20190278, 18407956
Q04603 (DPB4) S183 BioGRID 20190278, 21177495, 17563356
Q05027 (TAF9) T25 BioGRID 20190278
Q05471 (SWR1) T657 BioGRID 20190278
Q06224 (YSH1) S517 BioGRID 20190278, 17563356, 18407956
Q06488 (RSC2) T11 BioGRID 20190278
Q06505 (SPN1) S23 BioGRID 19795423, 19823750, 17563356, ...17330950, 20702584, 18407956, 19779198, 20190278, 19684113, 21177495
Q06697 (CDC73) S115 BioGRID 20190278
Q08561 (IES4) S2 BioGRID 19795423, 20190278, 21126336, ...19823750, 17693258
Q08561 (IES4) S5 BioGRID 17693258
Q08561 (IES4) S6 BioGRID 17693258
Q08561 (IES4) S9 BioGRID 17693258
Q08561 (IES4) S11 BioGRID 20190278, 18407956, 17693258
Q08773 (ISW2) S1082 BioGRID 17330950, 19779198, 20190278, ...17563356, 18407956
Q08887 (NDD1) S525 BioGRID 20190278
Q08949 (DDC1) T602 BioGRID 18541674, 20005839
Q12009 (TRM8) S7 BioGRID 17563356, 18407956
Q12030 (TAF10) S146 BioGRID 20190278, 18407956
Q12072 (IOC2) S262 BioGRID 19779198, 20190278, 18407956
Q12072 (IOC2) S605 BioGRID 20190278
Q12072 (IOC2) S760 BioGRID 20190278
Q12098 (SLX4) T72 BioGRID 17636031
Q12098 (SLX4) S289 BioGRID 17636031
Q12098 (SLX4) S329 BioGRID 17636031
Q12098 (SLX4) T457 BioGRID 20670896
Q12098 (SLX4) T474 BioGRID 20670896
Q12098 (SLX4) S499 BioGRID 18407956, 20670896
Q12098 (SLX4) T597 BioGRID 20670896
Q12098 (SLX4) S627 BioGRID 20670896
Q12098 (SLX4) S659 BioGRID 20670896
Q12098 (SLX4) S725 BioGRID 20190278, 20670896
Q12158 (MCD1) S307 BioGRID 20190278, 18407956
Q12248 (DAD1) S89 BioGRID 20190278
Q12406 (ARP7) S470 BioGRID 20190278
Q12432 (EAF3) S50 BioGRID 20190278, 17563356, 18407956
Q12455 (SPE4) S5 BioGRID 20190278, 18407956