iPTMnet Report for P37840 (SNCA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P37840 / SYUA_HUMAN
Protein Name Alpha-synuclein
Gene Name Name: SNCA
Synonyms:NACP,PARK1;
Organism Homo sapiens (Human)

PRO ID PR:P37840
DAG View
PRO Name alpha-synuclein (human)
Definition An alpha-synuclein that is encoded in the genome of human.
Short Label hSNCA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P37840 (SNCA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
M1 Acetylation UniProt 22407793
K6 Sumoylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
K10 Sumoylation PhosphoSitePlus
K12 Sumoylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
K21 Sumoylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
K23 Sumoylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
Y39 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 34648304, 27341336, 24412932
S42 Phosphorylation PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K45 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
T54 O-Glycosylation GlyGen   PhosphoSitePlus 28673834, 23584533, 18984734, ...35254053, 28657654, 31753312
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Sumoylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
T64 O-Glycosylation GlyGen 18984734, 31753312, 28673834, ...28657654, 35254053
T64 Phosphorylation PhosphoSitePlus
T72 O-Glycosylation GlyGen   PhosphoSitePlus 28673834, 18984734, 35254053, ...28657654, 31753312
T72 Phosphorylation PhosphoSitePlus
T75 O-Glycosylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Sumoylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T81 O-Glycosylation GlyGen   PhosphoSitePlus 28673834, 18984734, 35254053, ...28657654, 31753312
T81 Phosphorylation PhosphoSitePlus
S87 O-Glycosylation GlyGen   PhosphoSitePlus 28673834, 18984734, 35254053, ...28657654, 31753312
S87 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16959772, 10617630, 28195695, ...30805666, 25657004, 28550528
S87 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   Signor 25657004, 10617630
S87 Phosphorylation P68400 (CSNK2A1) Signor 10617630
S87 Phosphorylation Q13627 (DYRK1A) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16959772
K96 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K102 Sumoylation PhosphoSitePlus
Y125 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27341336, 25320964, 26807843, ...11078745, 22860160, 12096713, 11162638, 12893833, 22339654, 11744621, 19855133, 24434619, 26306801
Y125 Phosphorylation P06241 (FYN) neXtProt   phospho.ELM   PhosphoSitePlus 11162638, 26807843
Y125 Phosphorylation P12931 (SRC) PhosphoSitePlus 11078745
Y125 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11744621
Y125 Phosphorylation Q14289 (PTK2B) PhosphoSitePlus 12893833
S129 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24936070, 18343814, 30478174, ...34648304, 21945393, 26306801, 26807843, 25657004, 29725300, 16959772, 25452767, 32426502, 26782965, 24434619, 25109238, 26453202, 33138150, 27863657, 19203374, 18451726, 26475692, 22357655, 28990084, 16092093, 19493164, 20356833, 34220490, 30805666, 32568772, 34974168, 10617630, 28171705, 31555088, 35682892, 36304930, 26666838, 16957079, 19004816, 23314528, 32971383, 19576176, 30096435, 31507364, 23681749, 22090514, 20849899, 32356200, 27322472, 32143619, 25589666, 30219847, 30877431, 31068782, 21162130, 31257259, 17868672, 25637461, 14645218, 22892036, 35853942, 20725866, 26719332, 18562315, 24860424, 28855681, 23677647, 19410557, 26220523, 28877262, 32595456, 32624505, 33357908, 36114228, 26114655, 27341336, 33718373, 29669601, 28550528, 26346361, 19855133, 19889641, 25394490, 27003784, 23576548, 10852916, 27938414, 17146290, 27030050, 34973339, 22860160, 35905887, 29589283, 11813001
S129 Phosphorylation P25098 (GRK2) PhosphoSitePlus   Signor 10852916
S129 Phosphorylation P34947 (GRK5) neXtProt   PhosphoSitePlus   Signor 10852916, 16957079
S129 Phosphorylation P43250 (GRK6) neXtProt 19410557
S129 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   Signor 16959772, 18343814, 10617630, ...25657004
S129 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 25394490
S129 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 19889641
S129 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 10852916, 18562315, 10617630, ...11813001, 14645218
S129 Phosphorylation Q5S007 (LRRK2) Signor 19576176
S129 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   Signor 26807843, 19889641, 19004816
S129 Phosphorylation Q9NYY3 (PLK2) neXtProt   PhosphoSitePlus   Signor 25657004, 19004816, 19889641, ...20356833, 26719332
S129 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 10617630
Y133 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27341336, 25320964, 26807843, ...22860160, 24434619, 11744621
Y133 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11744621
Y136 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27341336, 25320964, 26807843, ...22860160, 24434619, 11744621
Y136 Phosphorylation P43405 (SYK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11744621
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 10852916
S9 Phosphorylation P43250 (GRK6) HPRD 10852916
S87 Phosphorylation HPRD 10617630
Y125 Phosphorylation HPRD 12096713, 11162638, 11744621
Y125 Phosphorylation P06241 (FYN) HPRD 12096713, 11162638, 11744621
Y125 Phosphorylation P07948 (LYN) HPRD 12096713, 11162638, 11744621
Y125 Phosphorylation P09769 (FGR) HPRD 12096713, 11162638, 11744621
Y125 Phosphorylation P43405 (SYK) HPRD 12096713, 11162638, 11744621
Y125 Phosphorylation Q14289 (PTK2B) HPRD 12096713, 11162638, 11744621
S129 Phosphorylation HPRD 10852916, 10617630
S129 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 10852916, 10617630
S129 Phosphorylation P19784 (CSNK2A2) HPRD 10852916, 10617630
S129 Phosphorylation P34947 (GRK5) HPRD 10852916, 10617630
S129 Phosphorylation P48730 (CSNK1D) HPRD 10852916, 10617630
S129 Phosphorylation P68400 (CSNK2A1) HPRD 10852916, 10617630
Y133 Phosphorylation HPRD 11744621
Y133 Phosphorylation P43405 (SYK) HPRD 11744621
Y136 Phosphorylation HPRD 11744621
Y136 Phosphorylation P43405 (SYK) HPRD 11744621
Site PTM Type PTM Enzyme Score Source PMID
S87 Phosphorylation HPRD 10617630
Y108 Phosphorylation HPRD 11744621
Y108 Phosphorylation P43405 (SYK) HPRD 11744621


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049305 (hSNCA/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43768 (ENSA) S109 P37840 (SNCA) inhibited_association eFIP 18973346


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 Y42 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T59 I59 Biomuta DOID:363 / uterine cancer [ icgc ]
T72 M72 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
K96 R96 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K96 E96 Biomuta DOID:4159 / skin cancer [ cosmic ]
S129 F129 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]