iPTMnet Report for P37275 (ZEB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P37275 / ZEB1_HUMAN
Protein Name Zinc finger E-box-binding homeobox 1
Gene Name Name: ZEB1
Synonyms:AREB6;
Organism Homo sapiens (Human)

PRO ID PR:P37275
DAG View
PRO Name zinc finger E-box-binding homeobox 1 (human)
Definition A zinc finger E-box-binding homeobox 1 that is encoded in the genome of human.
Short Label hZEB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P37275 (ZEB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S33 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T151 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S312 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S313 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S315 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S317 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S319 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S322 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T324 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K347 Sumoylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
K493 Sumoylation PhosphoSitePlus
K504 Sumoylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K515 Sumoylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus   RLIMS-P 25086746, 25476932
K613 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus   UniProt 19690332
S645 Phosphorylation PhosphoSitePlus
S646 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S679 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 19690332, ...20068231
S686 Phosphorylation PhosphoSitePlus
S693 Phosphorylation phospho.ELM 18669648
S698 Phosphorylation phospho.ELM 17081983
S700 Phosphorylation PhosphoSitePlus
S701 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T702 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S704 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S706 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T716 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus
T890 Phosphorylation PhosphoSitePlus
C909 Methylation IEDB 31844290
T927 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
T996 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
S1036 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
K1108 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation HPRD 17081983
S33 Phosphorylation HPRD 17081983
S312 Phosphorylation HPRD 18669648
S313 Phosphorylation HPRD 18669648
S315 Phosphorylation HPRD 18669648
S317 Phosphorylation HPRD 18669648
S319 Phosphorylation HPRD 18669648
S322 Phosphorylation HPRD 18669648
S583 Phosphorylation HPRD 19413330
S642 Phosphorylation HPRD 20068231
S645 Phosphorylation HPRD 20068231
S646 Phosphorylation HPRD 19413330, 18669648, 20068231
S673 Phosphorylation HPRD 20068231
S679 Phosphorylation HPRD 19651622, 15302935, 20068231
S693 Phosphorylation HPRD 18669648
S700 Phosphorylation HPRD 19651622
S701 Phosphorylation HPRD 18669648
T702 Phosphorylation HPRD 19413330, 19651622, 18669648
S704 Phosphorylation HPRD 19413330, 19651622
S706 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13363 (CTBP1) S422 P37275 (ZEB1) unknown eFIP 21224849


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 L33 Biomuta DOID:3571 / liver cancer [ cosmic ]
S155 N155 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S282 F282 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1319 / brain cancer [ cosmic ]
S313 L313 Biomuta DOID:4159 / skin cancer [ cosmic ]
S317 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K335 R335 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S342 F342 Biomuta DOID:4159 / skin cancer [ cosmic ]
S447 L447 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K493 R493 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K504 N504 Biomuta DOID:1324 / lung cancer [ cosmic ]
K504 Q504 Biomuta DOID:363 / uterine cancer [ icgc ]
K507 R507 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K515 Q515 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S646 Y646 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S646 F646 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S679 I679 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S686 F686 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S693 L693 Biomuta DOID:4159 / skin cancer [ cosmic ]
S698 F698 Biomuta DOID:4159 / skin cancer [ cosmic ]
S700 I700 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T702 A702 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S706 L706 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S850 N850 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S887 Y887 Biomuta DOID:4159 / skin cancer [ cosmic ]
T890 P890 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T996 I996 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1018 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S1022 L1022 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1022 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
K1108 N1108 Biomuta DOID:1324 / lung cancer [ cosmic ]